IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma

被引：3

作者：

Meng, Quan ^{[1
]}

Li, Can-Xuan ^{[2
]}

Long, Dan ^{[3
]}

Lin, Xiaobin ^{[4
]}

机构：

[1] Shenzhen Tradit Chinese Med Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Shenshan Cent Hosp, Dept Urol, Shanwei, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Shenshan Cent Hosp, Resp Med, Shanwei, Guangdong, Peoples R China

[4] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Breast Surg & Gen Surg, Guangzhou, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2021年 / 14卷

关键词：

IQGAP3; clear cell renal cell carcinoma; prognosis; CANCER; DNA; EXPRESSION;

D O I：

10.2147/IJGM.S316280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: The study was designed to mine the expression and roles of IQGAP3 in clear cell renal cell carcinoma (ccRCC). Methods: Expression profiles and clinical information were obtained from the Cancer Genome Atlas (TCGA) to estimate IQGAP3 expression in ccRCC, its relationship with patients' clinicopathological variables and prognosis, and the potential biological mechanisms. Results: IQGAP3 was highly expressed in ccRCC and indicated advanced clinical outcome and poor prognosis. IQGAP3 affected the progression of ccRCC through several cancer related pathways. IQGAP3 might play a vital role in the ccRCC tumor microenvironment. Conclusion: IQGAP3 could serve as a promising prognostic biomarker and therapeutic target.

引用

页码：3469 / 3484

页数：16

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