IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma

被引：3

作者：

Meng, Quan ^{[1
]}

Li, Can-Xuan ^{[2
]}

Long, Dan ^{[3
]}

Lin, Xiaobin ^{[4
]}

机构：

[1] Shenzhen Tradit Chinese Med Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Shenshan Cent Hosp, Dept Urol, Shanwei, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Shenshan Cent Hosp, Resp Med, Shanwei, Guangdong, Peoples R China

[4] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Breast Surg & Gen Surg, Guangzhou, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2021年 / 14卷

关键词：

IQGAP3; clear cell renal cell carcinoma; prognosis; CANCER; DNA; EXPRESSION;

D O I：

10.2147/IJGM.S316280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: The study was designed to mine the expression and roles of IQGAP3 in clear cell renal cell carcinoma (ccRCC). Methods: Expression profiles and clinical information were obtained from the Cancer Genome Atlas (TCGA) to estimate IQGAP3 expression in ccRCC, its relationship with patients' clinicopathological variables and prognosis, and the potential biological mechanisms. Results: IQGAP3 was highly expressed in ccRCC and indicated advanced clinical outcome and poor prognosis. IQGAP3 affected the progression of ccRCC through several cancer related pathways. IQGAP3 might play a vital role in the ccRCC tumor microenvironment. Conclusion: IQGAP3 could serve as a promising prognostic biomarker and therapeutic target.

引用

页码：3469 / 3484

页数：16

共 50 条

[1] IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability
Li, Wen
Wang, Zhifeng
Wang, Hanlin
Zhang, Jian
Wang, Xiaobin
Xing, Shaojun
Chen, Si
PEERJ, 2022, 10
[2] IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability
Li, Wen
Wang, Zhifeng
Wang, Hanlin
Zhang, Jian
Wang, Xiaobin
Xing, Shaojun
Chen, Si
PeerJ Computer Science, 2022, 10
[3] IQGAP3 can Serve as a Promising Biomarker for the Diagnosis of Endometrial Cancer
Liu, Wenyao
Meng, Qinghong
Du, Chengcheng
Sun, Chang
Hou, Shujuan
Li, Yu
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2024, 38 (05): : 3829 - 3837
[4] AURKB: a promising biomarker in clear cell renal cell carcinoma
Wan, Bangbei
Huang, Yuan
Liu, Bo
Lu, Likui
Lv, Cai
PEERJ, 2019, 7
[5] OSM May Serve as a Biomarker of Poor Prognosis in Clear Cell Renal Cell Carcinoma and Promote Tumor Cell Invasion and Migration
Wei, Shuzhang
Chen, Yin
Shi, Xiaokai
Zuo, Li
Zhang, Lifeng
INTERNATIONAL JOURNAL OF GENOMICS, 2023, 2023
[6] Immune-Associated Gene Signatures Serve as a Promising Biomarker of Immunotherapeutic Prognosis for Renal Clear Cell Carcinoma
Wang, Qi
Tang, Hanmin
Luo, Xuehui
Chen, Jie
Zhang, Xinyue
Li, Xinyue
Li, Yuesen
Chen, Yuetong
Xu, Yungang
Han, Suxia
FRONTIERS IN IMMUNOLOGY, 2022, 13
[7] MicroRNAs in Body Fluids: A More Promising Biomarker for Clear Cell Renal Cell Carcinoma
Shi, Lei
Wang, Mengheng
Li, Haiping
You, Pengtao
CANCER MANAGEMENT AND RESEARCH, 2021, 13 : 7663 - 7675
[8] CD276 is a promising biomarker for the prognosis of clear cell renal cell carcinoma
Yu, Yan-Hang
Xu, Jian-Hao
Chen, Hao
Lin, Yu-Xin
Ou-Yang, Jun
Zhang, Zhi-Yu
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2024, 40 (10): : 926 - 933
[9] FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis
Zhang, Yixiao
Zhu, Xudong
Qiao, Xinbo
Sun, Lisha
Tian, Ye
Yang, Yongliang
Zhao, Yuhong
Liu, Caigang
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2020, 17 (17): : 2819 - 2825
[10] IQGAP1 EXPRESSION AND SURVIVAL IN CLEAR CELL RENAL CELL CARCINOMA
Barbosa, Philip
Hammam, Olfat
Nolley, Rosalie
Metzner, Thomas
Fan, Alice
Srinivas, Sandy
Peehl, Donna
Brooks, James
Leppert, John
Alto, Palo
JOURNAL OF UROLOGY, 2014, 191 (04): : E306 - E307

← 1 2 3 4 5 →