An efficient catalyst-free one-pot synthesis of primary amides from the aldehydes of the Baylis-Hillman reaction

被引：13

作者：

Reddy, Thatikonda Narendar ^{[1
,2
]}

Raktani, Bikshapathi ^{[1
,2
]}

Perla, Ramesh ^{[3
]}

Ravinder, Mettu ^{[1
,2
]}

Vaidya, Jayathirtha Rao ^{[1
,2
]}

Babu, N. Jagadeesh ^{[4
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Crop Protect Chem Div, Uppal Rd, Hyderabad 500007, Andhra Prades, India

[2] Indian Inst Chem Technol, CSIR, AcSIR, Uppal Rd, Hyderabad 500007, Andhra Prades, India

[3] Indian Inst Chem Technol, CSIR, Nat Prod Chem Div, Hyderabad 500007, Andhra Prades, India

[4] Indian Inst Chem Technol, CSIR, Ctr Xray Crystallog, Hyderabad 500007, Andhra Prades, India

来源：

NEW JOURNAL OF CHEMISTRY | 2017年 / 41卷 / 17期

关键词：

KNOEVENAGEL CONDENSATION; ALPHA; BETA-UNSATURATED AMIDES; CONVENIENT SYNTHESIS; OXIDATIVE AMIDATION; AEROBIC OXIDATION; DIRECT CONVERSION; GREEN PROCEDURE; MILD AMIDATION; N-FORMYLATION; IONIC LIQUID;

D O I：

10.1039/c7nj01965c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, a facile and efficient method for the preparation of allyl amides from the aldehyde of Baylis-Hillman adducts has been developed using a hydroxylamine/methanol system under a catalyst-free condition. The effects of solvents and temperature on the reaction and substituents on the phenyl ring have been examined. This method is best demonstrated by its advantages such as operational simplicity, moderate to excellent yields, short reaction time, and simple reaction procedure. Most importantly, the reaction proceeds smoothly in the absence of a catalyst and an external oxidant.

引用

页码：9203 / 9209

页数：7

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