Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines

被引：22

作者：

Vitale, P. ^{[1
,2
]}

Scilimati, A. ^{[2
]}

机构：

[1] CINMPIS Interuniv Consortium Innovat Methodol & P, Bari, Italy

[2] Univ Bari A Moro, Dept Pharm Pharmaceut Sci, Bari, Italy

来源：

ADVANCES IN HETEROCYCLIC CHEMISTRY, VOL 122 | 2017年 / 122卷

关键词：

3-Aryl-2-isoxazolines; 3-Arylisoxazoles; 4,5-Dihydroisoxazoles; Isoxazole synthesis; Isoxazoline synthesis; Pharmacological activity; 5-MEMBERED RING-SYSTEMS; ARYL NITRILE OXIDES; ONE-POT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; COPPER(I)-CATALYZED SYNTHESIS; 3,5-DISUBSTITUTED ISOXAZOLES; HYDROXYLAMINE DERIVATIVES; CONVENIENT SYNTHESIS; REUPTAKE INHIBITION; EFFICIENT SYNTHESIS;

D O I：

10.1016/bs.aihch.2016.10.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Arylisoxazoles and 3-aryl-2-isoxazolines are versatile building blocks in organic chemistry. They are components of a wide number of pharmaceutical products and biologically active molecules. This chapter describes developments in the chemistry of these heterocycles, focusing on synthetic methods and reactivity studies published in the years 2005-2016. Particular attention is given to the regioselectivity of synthetic methods and their application to the preparation of pharmacological active compounds.

引用

页码：1 / 41

页数：41

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