Guanine binding to dirhodium tetracarboxylate anticancer complexes: quantum chemical calculations unravel an elusive mechanism

被引:0
|
作者
Deubel, Dirk V.
Chifotides, Helen T.
机构
[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA
[2] ETH, D CHAB, Zurich, Switzerland
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中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The reaction mechanism leading to metalated DNA fragments in which guanine-N7,O6 spans the metal-metal bond of dirhodium antitumour complexes in a bridging fashion at equatorial sites has been unravelled by a comprehensive prediction of intermediates and transition states.
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页码:3438 / 3440
页数:3
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