Epidemiology, risk factors, and the promotion of pancreatic cancer: Role of the stellate cell

被引：101

作者：

Pandol, Stephen

Gukovskaya, Anna

Edderkoui, Mouad

Dawson, David

Eibl, Guido

Lugea, Aurelia

机构：

[1] Univ Calif Los Angeles, So Calif Res Ctr Alcohol Liver & Pancreat Dis, Los Angeles, CA USA

[2] Dept Vet Affairs, Los Angeles, CA USA

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2012年 / 27卷

关键词：

diabetes; obesity; pancreatic cancer; smoking; stellate cell; BODY-MASS INDEX; INSULIN-RESISTANCE; MATRIX SYNTHESIS; ADIPOSE-TISSUE; OXIDIZED LDL; METAANALYSIS; ALCOHOL; SMOKING; PROLIFERATION; EXPRESSION;

D O I：

10.1111/j.1440-1746.2011.07013.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There are approximately 277 000 new cases of pancreatic cancer and 266 000 deaths from pancreatic cancer annually, indicating a mortality rate of 96% of the cases diagnosed. Because of the ineffectiveness of therapies, a major emphasis needs to be placed on prevention. This paper reviews the epidemiology and risk factors for pancreatic cancer, and uses this information to propose plausible research directions for determining the biological mechanisms mediating the effects of risk factors on the promotion of pancreatic cancer, with a focus on the pancreatic stellate cell.

引用

页码：127 / 134

页数：8

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