Direct carbocyclization of aldehydes with alkynes: Combining gold catalysis with aminocatalysis

被引：131
|
作者：
Binder, Jorg T. [1 ]
Crone, Benedikt [1 ]
Haug, Timm T. [1 ]
Menz, Helge [1 ]
Kirsch, Stefan F. [1 ]
机构：
[1] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 05期
关键词：
D O I：
10.1021/ol800092p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A combination of gold(l) complexes and amine bases catalyzes the 5-exo-dig cyclization of formyl alkynes. This direct alpha-functionalization of aldehydes with unactivated alkynes does not involve the use of preformed enol equivalents.
引用
收藏
页码：1025 / 1028
页数：4
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