Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones

被引：4

作者：

Jones, Raymond C. F. ^{[1
]}

Choudhury, Abdul K. ^{[1
]}

Iley, James N. ^{[2
]}

Light, Mark E. ^{[3
]}

Loizou, Georgia ^{[2
]}

Pillainayagam, Terence A. ^{[1
]}

机构：

[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] Open Univ, Dept Chem & Analyt Sci, Milton Keynes MK7 6AA, Bucks, England

[3] Univ Southampton, EPSRC Natl Crystallog Serv, Sch Chem, Southampton SO17 1BJ, Hants, England

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 8卷

关键词：

aldol reaction; fused-ring systems; heterocycles; isoxazole; metalation; pyridone; 1,3-DIPOLAR CYCLOADDITION ROUTE; ENTOMOPATHOGENIC FUNGUS; HETEROCYCLIC TRIONES; BEAUVERIA-BASSIANA; TENELLIN; METABOLITES; ACIDS;

D O I：

10.3762/bjoc.8.33

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3( Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products.

引用

页码：308 / 312

页数：5

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