Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones

被引：4
|
作者：
Jones, Raymond C. F. [1 ]
Choudhury, Abdul K. [1 ]
Iley, James N. [2 ]
Light, Mark E. [3 ]
Loizou, Georgia [2 ]
Pillainayagam, Terence A. [1 ]
机构：
[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England
[2] Open Univ, Dept Chem & Analyt Sci, Milton Keynes MK7 6AA, Bucks, England
[3] Univ Southampton, EPSRC Natl Crystallog Serv, Sch Chem, Southampton SO17 1BJ, Hants, England
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 8卷
关键词：
aldol reaction; fused-ring systems; heterocycles; isoxazole; metalation; pyridone; 1,3-DIPOLAR CYCLOADDITION ROUTE; ENTOMOPATHOGENIC FUNGUS; HETEROCYCLIC TRIONES; BEAUVERIA-BASSIANA; TENELLIN; METABOLITES; ACIDS;
D O I：
10.3762/bjoc.8.33
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3( Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products.
引用
收藏
页码：308 / 312
页数：5
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