DNA Repair Gene 8-Oxoguanine DNA Glycosylase Ser326Cys Polymorphism and Colorectal Cancer Risk in a Kashmiri Population

被引：18

作者：

Sameer, A. Syed ^{[1
]}

Nissar, Saniya ^{[1
]}

Abdullah, Safiya ^{[1
]}

Chowdri, Nissar A. ^{[2
]}

Siddiqi, Mushtaq A. ^{[1
]}

机构：

[1] Sherikashmir Inst Med Sci, Dept Immunol & Mol Med, Srinagar 190011, Kashmir, India

[2] Sherikashmir Inst Med Sci, Dept Gen Surg, Srinagar 190011, Kashmir, India

来源：

DNA AND CELL BIOLOGY | 2012年 / 31卷 / 04期

关键词：

SQUAMOUS-CELL CARCINOMA; ENVIRONMENTAL-FACTORS; NO ASSOCIATION; GASTRIC-CANCER; DAMAGED DNA; HOGG1; GENE; OGG1; 8-HYDROXYGUANINE; ESOPHAGEAL; COLON;

D O I：

10.1089/dna.2011.1349

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

8-Oxoguanine DNA glycosylase (OGG1) is one of the important base excision repair enzymes that repair 8-oxoguanine lesion incorporated within the DNA of an individual by reactive oxygen species. The aim of this study was to detect the role of OGG1 Ser326Cys polymorphism in susceptibility to colorectal cancer (CRC) in a Kashmiri population. We investigated the genotype distribution of the OGG1 gene in 114 CRC cases in comparison with 200 healthy subjects. There was no significant association between OGG1 Ser326Cys polymorphism and CRC, but the homozygous Cys/Cys variant genotype was associated with an increased risk of colon cancer (p < 0.05). This study suggests that the OGG1 polymorphism is not associated with the risk of development of CRC in the Kashmiri population in general but modulates the risk of cancer development in colon via interaction with many dietary factors.

引用

页码：541 / 546

页数：6

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