Synthesis and antimicrobial activity of 2-substituted-2,3-dihydro-1H-naphtho-[1,8-de]-1,3,2-diazaphosphorine 2-oxides/sulfides

被引：0
|
作者：
Venugopal, M
Reddy, CD [1 ]
Bavaji, M
机构：
[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
[2] Sri Venkateswara Univ, Dept Bot, Tirupati 517502, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2001年 / 40卷 / 09期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Several 2-alkylcarbamato/thiocarbamato/arylcarbamido/trichloromethy/bis(2-chloro-ethyl)amino/chloroethoxy/aryloxy-2,3-dihydro-1H-naphtho-[1,8-de]-1,3,2-diazaphosphorine 2-oxides/sulfides (4 and 6) are synthesized by reacting equimolar quantities of 1,8-diamino-naphthalene 1 with various dichlorophosphinyl carbamates/thiocarbamates/arylcarbamides 3a-1, trichloromethylphosphonic dichloride 5a, bis(2-chloroethyl)phosphoramidic dichloride 5b, O-2-chloroethyl phosphoryl chloride 5c and arylphosphorothioic dichlorides 5d-e in the presence of triethylamine at 45-65 degreesC. Their IR, H-1, C-13, P-31 NMR and mass spectral data are discussed. All these compounds are found to have significant antifungal and antibacterial activity.
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页码：822 / 827
页数：6
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