Synthesis and antimicrobial activity of 2-substituted-2,3-dihydro-1H-naphtho-[1,8-de]-1,3,2-diazaphosphorine 2-oxides/sulfides

被引：0
|
作者：
Venugopal, M
Reddy, CD [1 ]
Bavaji, M
机构：
[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
[2] Sri Venkateswara Univ, Dept Bot, Tirupati 517502, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2001年 / 40卷 / 09期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Several 2-alkylcarbamato/thiocarbamato/arylcarbamido/trichloromethy/bis(2-chloro-ethyl)amino/chloroethoxy/aryloxy-2,3-dihydro-1H-naphtho-[1,8-de]-1,3,2-diazaphosphorine 2-oxides/sulfides (4 and 6) are synthesized by reacting equimolar quantities of 1,8-diamino-naphthalene 1 with various dichlorophosphinyl carbamates/thiocarbamates/arylcarbamides 3a-1, trichloromethylphosphonic dichloride 5a, bis(2-chloroethyl)phosphoramidic dichloride 5b, O-2-chloroethyl phosphoryl chloride 5c and arylphosphorothioic dichlorides 5d-e in the presence of triethylamine at 45-65 degreesC. Their IR, H-1, C-13, P-31 NMR and mass spectral data are discussed. All these compounds are found to have significant antifungal and antibacterial activity.
引用
收藏
页码：822 / 827
页数：6
相关论文
共 50 条
  • [1] SYNTHESES OF 2-(SUBSTITUTED PHENOXY)-2,3-DIHYDRO-1H-NAPHTHO-(1,8-DE)-1,3,2-DIAZAPHOSPHORINE 2-OXIDES
    REDDY, CD
    AMMANNI, H
    REDDY, RSN
    PROCEEDINGS OF THE INDIAN ACADEMY OF SCIENCES-CHEMICAL SCIENCES, 1988, 100 (06): : 477 - 481
  • [2] QSAR studies of 2-substituted 2,3-dihydro-1h-naphtho[1,8-de]-1,3,2-diazaphosphorine 2-oxides and sulphides
    Madhuritha, AS
    Kumar, BA
    Parthasarathy, T
    Uma, V
    CENTRAL EUROPEAN JOURNAL OF CHEMISTRY, 2004, 2 (04): : 696 - 702
  • [3] Synthesis of 2-substituted-2,3-dihydro-5-benzoyl-1H-1,3,2-benzodiazaphosphole 2-oxides/sulfides
    Reddy, PVG
    Babu, YH
    Reddy, CS
    Srinivasulu, D
    HETEROATOM CHEMISTRY, 2002, 13 (04) : 340 - 345
  • [4] Synthesis and antimicrobial activity of 2-substituted-2,3-dihydro-5-propoxy-1H-1,3,2-benzodiazaphosphole 2-oxides
    Venugopal, M
    Reddy, BS
    Reddy, CD
    Berlin, KD
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 38 (01) : 275 - 279
  • [5] Synthesis and antimicrobial activity of 2-substituted-2,3-dihydro-5-thiophenoxy-1H-1,3,2-benzodiazaphosphole 2-oxides
    Rao, LN
    Nagaraju, C
    Reddy, CD
    Auschwitz, TS
    Brown, CW
    Klucik, J
    Hickey, MR
    Wakefield, CA
    Berlin, KD
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2000, 158 : 39 - 56
  • [6] Syntheses and antimicrobial activity of 2-substituted-2,3-dihydro-3-(4′-bromophenyl)-1H-naphth[1,2-e][1,3,2]oxazaphosphorin 2-oxides/sulfides
    Srinivasulu, D
    Reddy, CD
    Reddy, CS
    Brown, CW
    Hager, JD
    Means, M
    Berlin, KD
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2000, 167 : 181 - 193
  • [7] 2,3-DIHYDRO-1H-NAPHTHO[1,8-de][1,3]DIPHOSPHININES
    Tarasevych, Arkadii
    Rozhenko, Alexander
    Roeschenthaler, Gerd-Volker
    Shevchenko, Igor
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2011, 186 (04) : 841 - 844
  • [8] 1,3,2-DIAZAPHOSPHORINE 2-OXIDES .3. PREPARATION AND BIOLOGICAL EVALUATION OF SOME 1,3-BIS(ARALKYL)-2-HALO-1,3,2-DIAZAPHOSPHORINE 2-OXIDES AND RELATED COMPOUNDS
    BILLMAN, JH
    MEISENHEIMER, JL
    MAY, RF
    JOURNAL OF MEDICINAL CHEMISTRY, 1966, 9 (05) : 772 - +
  • [9] Synthesis of 2-substituted-2,3-dihydro-3-(2-nitrophenyl)-1H-naphth[1,2-e] [1,3,2]oxazaphosphorine 2-oxides
    Venugopal, M
    Reddy, CD
    Raju, CN
    Berlin, KD
    HETEROCYCLIC COMMUNICATIONS, 2000, 6 (03) : 253 - 258
  • [10] Synthesis and antimicrobial activity of 2-aryloxy-2,3-dihydro-5-propylthio-1H-1,3,2-benzodiazaphosphole 2-oxides
    Srinivasulu, D
    Nagaraju, C
    Reddy, CD
    Berlin, KD
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1999, 38 (06): : 735 - 738
12345