Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c] pyridin-4(5H)-ones

被引：7
|
作者：
Zhang, Zhiguo [1 ,3 ]
Gao, Xiaolong [1 ]
Wan, Yameng [1 ]
Huang, Yuanyuan [1 ]
Huang, Guoqing [2 ]
Zhang, Guisheng [1 ]
机构：
[1] Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Collaborat Innovat Ctr Henan Prov Green Mfg Fine C, Key Lab Green Chem Media & React,Minist Educ,Sch C, Xinxiang 453007, Henan, Peoples R China
[2] Handan Purificat Equipment Res Inst, Handan 056027, Hebei, Peoples R China
[3] Northeast Normal Univ, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Jilin, Peoples R China
来源：
ACS OMEGA | 2017年 / 2卷 / 10期
关键词：
INVESTIGATIONAL DRUG TAK-441; INTRAMOLECULAR CYCLIZATION; ACTIVATED CYCLOPROPANES; DOMINO REACTION; CATALYST-FREE; DERIVATIVES; INHIBITORS; OXIDATION; CASCADE; NH4OAC;
D O I：
10.1021/acsomega.7b00626
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient tandem intermolecular one-pot aldol condensation/aza-addition reaction of 2-methyl-3-carbamoylpyrroles and aldehydes was developed for the synthesis of 2,3,6,7-tetrahydro-1H-pyrrolo[3,2-c] pyridin4(5H)-ones. The reaction proceeded using only 3.0 equiv of ammonium acetate promoter in green solvent poly(ethylene glycol)-400 at 100 degrees C to afford a series of pyrrolo[3,2-c] pyridinone derivatives in good to excellent yields.
引用
收藏
页码：6844 / 6851
页数：8
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