Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c] pyridin-4(5H)-ones

被引：7

作者：

Zhang, Zhiguo ^{[1
,3
]}

Gao, Xiaolong ^{[1
]}

Wan, Yameng ^{[1
]}

Huang, Yuanyuan ^{[1
]}

Huang, Guoqing ^{[2
]}

Zhang, Guisheng ^{[1
]}

机构：

[1] Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Collaborat Innovat Ctr Henan Prov Green Mfg Fine C, Key Lab Green Chem Media & React,Minist Educ,Sch C, Xinxiang 453007, Henan, Peoples R China

[2] Handan Purificat Equipment Res Inst, Handan 056027, Hebei, Peoples R China

[3] Northeast Normal Univ, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Jilin, Peoples R China

来源：

ACS OMEGA | 2017年 / 2卷 / 10期

关键词：

INVESTIGATIONAL DRUG TAK-441; INTRAMOLECULAR CYCLIZATION; ACTIVATED CYCLOPROPANES; DOMINO REACTION; CATALYST-FREE; DERIVATIVES; INHIBITORS; OXIDATION; CASCADE; NH4OAC;

D O I：

10.1021/acsomega.7b00626

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient tandem intermolecular one-pot aldol condensation/aza-addition reaction of 2-methyl-3-carbamoylpyrroles and aldehydes was developed for the synthesis of 2,3,6,7-tetrahydro-1H-pyrrolo[3,2-c] pyridin4(5H)-ones. The reaction proceeded using only 3.0 equiv of ammonium acetate promoter in green solvent poly(ethylene glycol)-400 at 100 degrees C to afford a series of pyrrolo[3,2-c] pyridinone derivatives in good to excellent yields.

引用

页码：6844 / 6851

页数：8

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