A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

被引：6

作者：

Huang, Chun-Ming ^{[1
,2
,3
]}

Torpey, Justin W. ^{[4
]}

Liu, Yu-Tseung ^{[3
]}

Chen, Yun-Ru ^{[1
,2
]}

Williams, Katherine E. ^{[5
]}

Komives, Elizabeth A. ^{[4
]}

Gallo, Richard L. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Dermatol, San Diego, CA 92103 USA

[2] VA San Diego Healthcare Ctr, San Diego, CA USA

[3] Univ Calif San Diego, Moores Canc Ctr, San Diego, CA 92103 USA

[4] Univ Calif San Diego, Dept Chem & Biochem, San Diego, CA 92103 USA

[5] Appl Biosyst Inc, Foster City, CA 94404 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 05期

关键词：

D O I：

10.1128/AAC.01347-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

引用

页码：1834 / 1836

页数：3

共 31 条

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Otero-Gonzalez, Anselmo J.
Weil, Tanja
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Staendker, Ludger
Vogel, Verena
Spellerberg, Barbara
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