Inhibition of Geranylgeranylacetone on cholecystokinin-B receptor, BDNF and dopamine D1 receptor induced by morphine

被引:6
|
作者
Guo, Ningning [1 ,2 ]
Zhang, Le [1 ]
Fan, Wei [1 ]
Bai, Liping [1 ,2 ]
Zhang, Xianwen [1 ]
Shi, Zhizhou [1 ]
Bai, Jie [1 ]
机构
[1] Kunming Univ Sci & Technol, Med Sch, 727 Jingming South Rd, Kunming 650500, Yunnan, Peoples R China
[2] Kunming Univ Sci & Technol, Fac Environm Sci & Engn, Kunming 650500, Yunnan, Peoples R China
基金
中国国家自然科学基金;
关键词
Morphine; Conditioned place preference; Geranylgeranylacetone; Cholecystokinin-B receptor; Brain-derived neurotrophic factor; CONDITIONED PLACE PREFERENCE; NUCLEUS-ACCUMBENS; SYNAPTIC PLASTICITY; EXPRESSION; REWARD; ACQUISITION; ANTAGONISTS; WITHDRAWAL; DEPENDENCE; MIDBRAIN;
D O I
10.1016/j.bbrc.2021.12.034
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Morphine is the pain releasing and abusing drug. Morphine leads to addiction by activating dopaminergic rewarding system consisted of the ventral tegmental area (VTA) and nucleus accumbens (NAc). Cholecystokinin (CCK) is a gut-brain neuropeptide and involved in morphine dependence. Brain-derived neurotrophic factor (BDNF) is a neurotrophin and plays roles in regulating addiction. Geranylgeranylacetone (GGA) is a medicine of protecting gastric mucosal injury and protecting neurons. Our previous study showed that GGA blocked morphine-induced withdrawal and relapse through inducing thioredoxin 1(Trx1). In this study, we investigated that whether cholecystokinin-B receptor (CCKB receptor) and BDNF were related to GGA inhibition on morphine addiction. At first, we made conditioned place preference (CPP) model and confirmed again that GGA blocked the expression of morphine-CPP in present study. Then, our results showed that morphine increased the expressions of dopamine D1 receptor, tyrosine hydroxylase (TH), CCKB receptor and BDNF in the VTA and NAc in mice, which was inhibited by GGA. These results suggest that CCK and BDNF in dopaminergic systems are associated with the role of GGA blocking morphine-CPP. (C) 2021 The Authors. Published by Elsevier Inc.
引用
收藏
页码:23 / 28
页数:6
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