Snail regulates Hippo signalling-mediated cell proliferation and tissue growth in Drosophila

被引：4
|
作者：
Ding, Xiang [1 ]
Li, Zhuojie [1 ]
Peng, Kai [1 ]
Zou, Rui [1 ]
Wu, Chenxi [1 ,2 ]
Lin, Gufa [3 ]
Li, Wenzhe [1 ]
Xue, Lei [1 ,4 ,5 ]
机构：
[1] Tongji Univ, Inst Intervent Vessel, Shanghai 10th Peoples Hosp, Shanghai Key Lab Signaling & Dis Res,Sch Life Sci, Shanghai, Peoples R China
[2] North China Univ Sci & Technol, Coll Tradit Chinese Med, Tangshan, Hebei, Peoples R China
[3] Tongji Univ, Key Lab Spine & Spinal Cord Injury Repair & Regen, Minist Educ, Orthopaed Dept,Tongji Hosp,Sch Life Sci & Technol, Shanghai, Peoples R China
[4] Jinan Univ, Zhuhai Hosp, Zhuhai Peoples Hosp, Zhuhai Precis Med Ctr, Zhuhai, Guangdong, Peoples R China
[5] Tongji Univ, Natl Clin Res Ctr Intervent Med, Shanghai 10th Peoples Hosp, Shanghai, Peoples R China
来源：
OPEN BIOLOGY | 2022年 / 12卷 / 03期
基金：
中国国家自然科学基金;
关键词：
snail; Hippo pathway; tissue growth; cell proliferation; Drosophila; ZINC-FINGER PROTEINS; TUMOR-SUPPRESSOR; ORGAN SIZE; TEAD/TEF FAMILY; PATHWAY; YORKIE; EXPRESSION; APOPTOSIS; HOMOLOG; KINASE;
D O I：
10.1098/rsob.210357
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Snail (Sna) plays a pivotal role in epithelia-mesenchymal transition and cancer metastasis, yet its functions in normal tissue development remain elusive. Here, using Drosophila as a model organism, we identified Sna as an essential regulator of Hippo signalling-mediated cell proliferation and tissue growth. First, Sna is necessary and sufficient for impaired Hippo signalling-induced cell proliferation and tissue overgrowth. Second, Sna is necessary and sufficient for the expression of Hippo pathway target genes. Third, genetic epistasis data indicate Sna acts downstream of Yki in the Hippo signalling. Finally, Sna is physiologically required for tissue growth in normal development. Mechanistically, Yki activates the transcription of sna, whose protein product binds to Scalloped (Sd) and promotes Sd-dependent cell proliferation. Thus, this study uncovered a previously unknown physiological function of Sna in normal tissue development and revealed the underlying mechanism by which Sna modulates Hippo signalling-mediated cell proliferation and tissue growth.
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页数：11
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