Association of the adiponectin rs266729 C > G variant and coronary heart disease in the low risk 'Golden Years' type 1 diabetes cohort

被引：12
|
作者：
Prior, Sarah L. [1 ]
Jones, Danielle A. [1 ]
Gill, Geoffrey V. [2 ]
Bain, Steve C. [1 ]
Stephens, Jeffrey W. [1 ]
机构：
[1] Swansea Univ, Inst Life Sci, Diabet Res Grp, Swansea SA2 8PP, W Glam, Wales
[2] Univ Liverpool, Dept Endocrinol & Diabet, Ctr Clin Sci, Univ Hosp Aintree, Liverpool L9 1AE, Merseyside, England
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2011年 / 91卷 / 03期
关键词：
Adiponectin; Gene variant; Coronary heart disease; Obesity; Type; 1; diabetes; SUSCEPTIBILITY LOCUS; SERUM ADIPONECTIN; NEPHROPATHY; METAANALYSIS; LINKAGE;
D O I：
10.1016/j.diabres.2010.12.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The C-allele of rs266729 is associated with CHD, while the G-allele of rs17300539 is associated with metabolic traits. We examined these in type 1 diabetes. For rs266729, the C-allele was associated with 8-fold increase in CHD. For rs17300539, the G-allele was associated with increases in triglycerides and waist circumference. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：E71 / E74
页数：4
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