PrP genotype frequencies of the most dominant sheep breed in a country free from scrapie

被引：41
|
作者：
Bossers, A [1 ]
Harders, FL [1 ]
Smits, MA [1 ]
机构：
[1] DLO, Inst Anim Sci & Hlth, NL-8200 AB Lelystad, Netherlands
来源：
ARCHIVES OF VIROLOGY | 1999年 / 144卷 / 04期
关键词：
D O I：
10.1007/s007050050548
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Polymorphisms within the prion protein (PrP) gene are associated with scrapie susceptibility. We analysed the PrP genes of 140 Romney Marsh sheep, the dominant breed in New Zealand, a country free from scrapie. We found PrP alleles that are associated with a high susceptibility to scrapie. Sheep with these PrP genotypes would probably succumb to scrapie when born and raised in a scrapie endemic environment. These findings correspond to those obtained in minor breeds from New Zealand. We conclude that scrapie development not only depends on host genetic factors but also requires exogenous factors. Our findings demonstrate the effectiveness of the measures taken by New Zealand to maintain free from scrapie.
引用
收藏
页码：829 / 834
页数：6
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