p70 S6 kinase: An enigma with variations

被引:195
|
作者
Proud, CG
机构
[1] Department of Biosciences, University of Kent at Canterbury, Canterbury
关键词
D O I
10.1016/S0968-0004(96)10016-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The S6 ribosomal protein is phosphorylated by p70 S6 kinase (p70(S6k)), Although the cellular role of S6 phosphorylation is still not fully clear, studies on p70(S6k) and its activation have revealed the existence of a novel signalling pathway, clues to the mechanism of action of certain immunosuppressants and insights into the control of gene expression at the levels of transcription and translation.
引用
收藏
页码:181 / 185
页数:5
相关论文
共 50 条
  • [41] RAPAMYCIN SELECTIVELY INHIBITS INTERLEUKIN-2 ACTIVATION OF P70 S6 KINASE
    KUO, CJ
    CHUNG, JK
    FIORENTINO, DF
    FLANAGAN, WM
    BLENIS, J
    CRABTREE, GR
    NATURE, 1992, 358 (6381) : 70 - 73
  • [42] Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer
    Nozawa, Hiroaki
    Watanabe, Toshiaki
    Nagawa, Hirokazu
    CANCER LETTERS, 2007, 251 (01) : 105 - 113
  • [43] Astaxanthin Inhibits p70 S6 Kinase 1 Activity to Sensitize Insulin Signaling
    Li, Chunmei
    Ma, Bixia
    Chen, Junhong
    Jeong, Yoonhwa
    Xu, Xiulong
    MARINE DRUGS, 2020, 18 (10)
  • [44] P70 S6 kinase assay: A pharmacodynamic monitoring strategy for rapamycin assay development
    Gallant, HL
    Yatscoff, RW
    TRANSPLANTATION PROCEEDINGS, 1996, 28 (06) : 3058 - 3061
  • [45] Amino acid availability regulates p70 S6 kinase and multiple translation factors
    Wang, XM
    Campbell, LE
    Miller, CM
    Proud, CG
    BIOCHEMICAL JOURNAL, 1998, 334 : 261 - 267
  • [46] Amino acid availability regulates p70 S6 kinase and multiple translation factors
    Wang, X.
    Campbell, L.E.
    Miller, C.M.
    Proud, C.G.
    Biochemical Journal, 1998, 334 (pt 1): : 261 - 267
  • [47] Estradiol enhances CIP2A expression by the activation of p70 S6 kinase
    Choi, Yeon A.
    Koo, Ja Seung
    Park, Jeong Su
    Park, Mi Young
    Jeong, Ae Lee
    Oh, Ki-Sook
    Yang, Young
    ENDOCRINE-RELATED CANCER, 2014, 21 (02) : 189 - 202
  • [48] Phosphorylation and activation of p70 S6 kinase by manganese in PC12 cells
    Hirata, Y
    Adachi, K
    Kiuchi, K
    NEUROREPORT, 1998, 9 (13) : 3037 - 3040
  • [49] COMPARISON OF THE SPECIFICITIES OF P70 S6 KINASE AND MAPKAP KINASE-1 IDENTIFIES A RELATIVELY SPECIFIC SUBSTRATE FOR P70 S6 KINASE - THE N-TERMINAL KINASE DOMAIN OF MAPKAP KINASE-1 IS ESSENTIAL FOR PEPTIDE PHOSPHORYLATION
    LEIGHTON, IA
    DALBY, KN
    CAUDWELL, FB
    COHEN, PTW
    COHEN, P
    FEBS LETTERS, 1995, 375 (03) : 289 - 293
  • [50] Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis
    Blouet, Clemence
    Ono, Hiraku
    Schwartz, Gary J.
    CELL METABOLISM, 2008, 8 (06) : 459 - 467