Malignant melanoma as second malignant neoplasm in long-term childhood cancer survivors: A systematic review

被引：24
|
作者：
Braam, Katja. I. [1 ]
Overbeek, Annelies [1 ]
Kaspers, Gertjan J. L. [1 ]
Ronckers, Cecile M. [2 ,3 ]
Schouten-van Meeteren, Annette Y. N. [2 ]
Van Dulmen-Den Broeder, Eline [1 ]
Veening, Margreet A. [1 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Pediat, Div Hematol Oncol, NL-1007 MB Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Pediat, Div Pediat Oncol,Emma Childrens Hosp AMC EKZ, NL-1105 AZ Amsterdam, Netherlands
[3] Long Term Effects Childhood Canc DCOG LATER, Dutch Childhood Oncol Grp, The Hague, Netherlands
来源：
PEDIATRIC BLOOD & CANCER | 2012年 / 58卷 / 05期
关键词：
childhood cancer; childhood cancer survivor; melanoma; second malignant neoplasm; ACUTE LYMPHOBLASTIC-LEUKEMIA; CAUSE-SPECIFIC MORTALITY; HODGKINS-DISEASE; FOLLOW-UP; SUBSEQUENT MALIGNANCIES; SECONDARY NEOPLASMS; PROGNOSTIC-FACTORS; MELANOCYTIC NEVI; RISK; RETINOBLASTOMA;
D O I：
10.1002/pbc.24023
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This systematic review provides information on malignant melanoma as second malignant neoplasm (SMN) after childhood cancer and evaluates its risk factors. Study reports describing incidences of SMN and malignant melanoma as SMN in a population of childhood cancer survivors (CCS) were included. Of 151,575 CCS, 4,010 (2.6%) children developed an SMN, 212 of which were melanoma (5.3% or 0.14% of all CCS). The following risk factors for malignant melanoma as SMN were identified: radiotherapy, or the combination alkylating agents and anti-mitotic drugs. Melanomas are most frequently observed after Hodgkin disease, hereditary retinoblastoma, soft tissue sarcoma, and gonadal tumors. Pediatr Blood Cancer (C) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：665 / 674
页数：10
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