Effects of N-terminal fragments of β-endorphin on feeding in chicks

被引：19
|
作者：
Yanagita, Kouichi [1 ]
Shiraishi, Jun-Ichi [1 ]
Fujita, Masanori [1 ]
Bungo, Takashi [1 ]
机构：
[1] Hiroshima Univ, Grad Sch Biosphere Sci, Lab Anim Behav & Physiol, Higashihiroshima 7398528, Japan
来源：
NEUROSCIENCE LETTERS | 2008年 / 442卷 / 02期
基金：
日本学术振兴会;
关键词：
beta-enclorphin; N-terminal fragment; feeding behavior; central nervous system; chick;
D O I：
10.1016/j.neulet.2008.07.018
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It is known that N-terminal fragments of beta-endorphin have biological activities, such as an antagonism effect of beta-endorphin (1-31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of beta-endorphin (1-27) (0.4 nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. beta-Endorphin (1-17) (2.0 nmol) also increased food intake at 30 min postinjection. Co-injection of either beta-endorphin (1-27) or (1-17) was effective in reducing full-length beta-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of beta-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：140 / 142
页数：3
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