N-TERMINAL AND C-TERMINAL FRAGMENTS OF THE HORMONE STANNIOCALCIN SHOW DIFFERENTIAL-EFFECTS IN EELS

被引:8
|
作者
VERBOST, PM [1 ]
FENWICK, JC [1 ]
机构
[1] UNIV OTTAWA, DEPT BIOL, OTTAWA, ON K1N 6N5, CANADA
关键词
D O I
10.1006/gcen.1995.1059
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of an N-terminal, a C-terminal, and a mid-fragment of stanniocalcin, the primary hypocalcemic hormone in fish, on plasma total and free (ionic) calcium levels and whole animal calcium influx were tested in eels. Both the N- and the C-terminal fragments were hypocalcemic, causing 18 and 12% reduction in plasma calcium in stanniectomized eels, respectively. With both fragments the hypocalcemic action is transient. The hypocalcemia caused by the C-terminal fragment, although more rapid, is not as pronounced as the hypocalcemic action of the N-terminal fragment. Only the C-terminal fragment reduced calcium influx. The hypocalcemic activity of the C-terminal fragment then can be explained by its effect on calcium influx. The N-terminal fragment appears to function in a different manner. The mid-fragment has no effect on plasma calcium or calcium influx. The different parts of the hormone are concluded to have different effects. (C) 1995 Academic Press, Inc.
引用
收藏
页码:185 / 192
页数:8
相关论文
共 50 条
  • [1] A C-TERMINAL FRAGMENT OF THE HORMONE STANNIOCALCIN IS BIOACTIVE IN EELS
    FENWICK, JC
    VERBOST, P
    [J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1993, 91 (03) : 337 - 343
  • [2] RECEPTOR-MODULATED IRON RELEASE FROM TRANSFERRIN - DIFFERENTIAL-EFFECTS ON N-TERMINAL AND C-TERMINAL SITES
    BALI, PK
    AISEN, P
    [J]. BIOCHEMISTRY, 1991, 30 (41) : 9947 - 9952
  • [3] SUBSTANCE-P AND BEHAVIOR - OPPOSITE EFFECTS OF N-TERMINAL AND C-TERMINAL FRAGMENTS
    HALL, ME
    STEWART, JM
    [J]. PEPTIDES, 1983, 4 (05) : 763 - 768
  • [4] STRUCTURAL STUDIES ON OVINE GROWTH HORMONE - CYANOGEN BROMIDE FRAGMENTS - N-TERMINAL AND C-TERMINAL SEQUENCES
    PENA, C
    PALADINI, AC
    DELLACHA, JM
    SANTOME, JA
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1970, 17 (01): : 27 - &
  • [5] ASSAYS OF CIRCULATING C-TERMINAL AND N-TERMINAL PARATHYROID-HORMONE FRAGMENTS AND CALCITONIN IN POSTMENOPAUSAL OSTEOPOROSIS
    MILHAUD, G
    DESPLAN, C
    JULLIENNE, A
    MOUKHTAR, MS
    [J]. CALCIFIED TISSUE RESEARCH, 1977, 24 : R17 - R17
  • [6] Functional and structural characterization of apidaecin and its N-terminal and C-terminal fragments
    Zhou, Xu-Xia
    Li, We-Fen
    Pan, Yuan-Jiang
    [J]. JOURNAL OF PEPTIDE SCIENCE, 2008, 14 (06) : 697 - 707
  • [7] N-TERMINAL MODIFIED ANALOGS OF C-TERMINAL FRAGMENTS OF PBAN WITH PHEROMONOTROPIC ACTIVITY
    KUNIYOSHI, H
    NAGASAWA, H
    ANDO, T
    SUZUKI, A
    [J]. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 22 (04) : 399 - 403
  • [8] Regulation of C-terminal and N-terminal fragments of HER2 by mRNA
    Miura, Daishu
    Kadowaki, Masami
    Tamura, Nobuko
    Kawabata, Hidetaka
    Fujii, Takeshi
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [9] ANALYSIS OF THE BEHAVIORAL ACTIVITY OF C-TERMINAL AND N-TERMINAL FRAGMENTS OF CHOLECYSTOKININ OCTAPEPTIDE
    CRAWLEY, JN
    STPIERRE, S
    GAUDREAU, P
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1984, 230 (02): : 438 - 444
  • [10] N-TERMINAL AND C-TERMINAL FRAGMENTS OF SUBSTANCE-P - SPINAL EFFECTS IN THE RAT TAIL FLICK TEST
    CRIDLAND, RA
    HENRY, JL
    [J]. BRAIN RESEARCH BULLETIN, 1988, 20 (04) : 429 - 432