INDOMETHACIN SOLUBILITY ESTIMATION IN 1,4-DIOXANE + WATER MIXTURES BY THE EXTENDED HILDEBRAND SOLUBILITY APPROACH

被引：6
|
作者：
Ruidiaz, Miller A. [1 ]
Delgado, Daniel R. [1 ]
Martinez, Fleming [1 ]
机构：
[1] Univ Nacl Colombia, Dept Farm, Fac Ciencias, Bogota 14490, Colombia
来源：
QUIMICA NOVA | 2011年 / 34卷 / 09期
关键词：
Extended Hildebrand Solubility Approach; indomethacin; solubility parameter; WATER COSOLVENT MIXTURES; SOLVENT MIXTURES; DRUGS;
D O I：
10.1590/S0100-40422011000900016
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Extended Hildebrand Solubility Approach (EHSA) was successfully applied to evaluate the solubility of Indomethacin in 1,4-dioxane + water mixtures at 298.15 K. An acceptable correlation-performance of EHSA was found by using a regular polynomial model in order four of the W interaction parameter vs. solubility parameter of the mixtures (overall deviation was 8.9%). Although the mean deviation obtained was similar to that obtained directly by means of an empiric regression of the experimental solubility vs. mixtures solubility parameters, the advantages of EHSA are evident because it requires physicochemical properties easily available for drugs.
引用
收藏
页码：1569 / 1574
页数：6
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