Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/sandostatin(R)

被引：33

作者：

Damour, D

Barreau, M

Blanchard, JC

Burgevin, MC

Doble, A

Herman, F

Pantel, G

JamesSurcouf, E

Vuilhorgne, M

Mignani, S

Poitout, L

LeMerrer, Y

Depezay, JC

机构：

[1] RHONE POULENC RORER SA,CTR RECH VITRY ALFORTVILLE,F-94403 VITRY SUR SEINE,FRANCE

[2] UNIV PARIS 05,CHIM & BIOCHIM PHARMACOL & TOXICOL LAB,CNRS,F-75270 PARIS 06,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 14期

关键词：

D O I：

10.1016/0960-894X(96)00289-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on molecular modelling studies of Sandostatin(R), sugar-based derivatives I-VI were prepared as potential non-peptide mimics of somatostatin/Sandostatin(R). These compounds displaced 3-[I-125]-Tyr(11)-SRIF-14 from the somatostatin receptor on membranes of rat cerebral cortex with IC50 values between 10 and 15 mu M. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1667 / 1672

页数：6

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