Small Angle X-ray Diffraction Study on DOPC plus DOPE Liposomes containing Long 1-Alkanols

被引：0

作者：

Klacsova, Maria ^{[1
,2
]}

Karlovska, Janka ^{[2
]}

Funari, Sergio S. ^{[3
]}

Balgavy, Pavol ^{[2
]}

机构：

[1] Comenius Univ, Fac Math Phys & Informat, Dept Nucl Phys & Biophys, Mlynska Dolina F2, Bratislava 84248, Slovakia

[2] Comenius Univ, Fac Pharm, Dept Phys Chem Drugs, Bratislava SK-83232, Slovakia

[3] DESY, HASYLAB, D-22603 Hamburg, Germany

来源：

NUCLEAR PHYSICS METHODS AND ACCELERATORS IN BIOLOGY AND MEDICINE | 2009年 / 1204卷

关键词：

phospholipids; alkanols; X-ray diffraction; hexagonal phase;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The effect of 1-alkanols (abbreviation CnOH, n = 8-18 is the even number of alkyl carbons) on the transition from lamellar L-alpha to inverted hexagonal H-II phase of multilamellar dioleylphosphatidylcholine (DOPC) + dioleylphosphatidylethanolamine (DOPE) vesicles at full hydration was studied using small angle X-ray diffraction. For DOPC:DOPE = 1:9 molar ratio the phase transition temperature T-BH was observed at similar to 40 degrees C. The CnOHs studied caused a significant decrease of T-BH. The hexagonal phase was observed at presence of shorter alkanols (C8OH - C14OH), at 0.4:1 alkanol:lipid molar ratio, even at 5 degrees C. For C16OH and C18OH the offset of L-alpha > H-II transition was detected.

引用

页码：231 / 233

页数：3

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