Small Angle X-ray Diffraction Study on DOPC plus DOPE Liposomes containing Long 1-Alkanols

被引：0
|
作者：
Klacsova, Maria [1 ,2 ]
Karlovska, Janka [2 ]
Funari, Sergio S. [3 ]
Balgavy, Pavol [2 ]
机构：
[1] Comenius Univ, Fac Math Phys & Informat, Dept Nucl Phys & Biophys, Mlynska Dolina F2, Bratislava 84248, Slovakia
[2] Comenius Univ, Fac Pharm, Dept Phys Chem Drugs, Bratislava SK-83232, Slovakia
[3] DESY, HASYLAB, D-22603 Hamburg, Germany
来源：
NUCLEAR PHYSICS METHODS AND ACCELERATORS IN BIOLOGY AND MEDICINE | 2009年 / 1204卷
关键词：
phospholipids; alkanols; X-ray diffraction; hexagonal phase;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The effect of 1-alkanols (abbreviation CnOH, n = 8-18 is the even number of alkyl carbons) on the transition from lamellar L-alpha to inverted hexagonal H-II phase of multilamellar dioleylphosphatidylcholine (DOPC) + dioleylphosphatidylethanolamine (DOPE) vesicles at full hydration was studied using small angle X-ray diffraction. For DOPC:DOPE = 1:9 molar ratio the phase transition temperature T-BH was observed at similar to 40 degrees C. The CnOHs studied caused a significant decrease of T-BH. The hexagonal phase was observed at presence of shorter alkanols (C8OH - C14OH), at 0.4:1 alkanol:lipid molar ratio, even at 5 degrees C. For C16OH and C18OH the offset of L-alpha > H-II transition was detected.
引用
收藏
页码：231 / 233
页数：3
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