Expression of CD52 in peripheral T-cell lymphoma

被引：48

作者：

Piccaluga, Pier Paolo ^{[1
]}

Agostinelli, Claudio ^{[1
]}

Righi, Simona ^{[1
]}

Zinzani, Pier Luigi ^{[1
]}

Pileri, Stefano A. ^{[1
]}

机构：

[1] Univ Bologna, Inst Hematol & Med Oncol L&A Seragnoli, S Orsola Malpighi Hosp, I-40138 Bologna, Italy

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 04期

关键词：

T-cell lymphoma; CD52; expression;

D O I：

10.3324/haematol.10767

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral T-cell lymphoma unspecified (PTCL/U) is a rare tumor characterized by poor treatment response and a dismal prognosis. We studied CD52 expression in 97 PTCL/U cases by immunohistochemistry on tissue-microarrays. Furthermore, CD52 gene expression was studied in 28 cases for which RNA was available. We found that CD52 is expressed in approximately 40% of PTCLs/U at the same level as in normal T-lymphocytes. Although other factors may play a role in the in vivo response to alemtuzumab, an anti-CD52 monoclonal antibody, the estimation of CD52 expression may provide a rationale for the selection of patients with a higher probability of treatment response.

引用

页码：566 / 567

页数：2

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