The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction

被引：13

作者：

Tyrrell, Elizabeth ^{[1
]}

Mazloumi, Khatebeh ^{[1
]}

Banti, Donatella ^{[1
]}

Sajdak, Paulina ^{[1
]}

Sinclair, Alex ^{[1
]}

Le Gresley, Adam ^{[1
]}

机构：

[1] Kingston Univ, Sch Chem & Pharm, Kingston KT1 2EE, Surrey, England

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 33期

关键词：

Nicholas cyclisation; Chromane; Isochromane; Asymmetric alkynylation; N-Methylephedrine; Enantiospecific reaction; ENANTIOSELECTIVE ALKYNYLATION REACTIONS; IN-SITU GENERATION; ALDEHYDES; BENZOPYRANS; SUBSTITUENTS; CHEMISTRY; ALCOHOLS; FACILE; MILD;

D O I：

10.1016/j.tetlet.2012.05.112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiospecific synthesis of chromanes and isochromanes obtained from an intramolecular Nicholas cyclisation reaction is discussed. During the course of this study we observed the formation of chroman-4-ones from a CAN deprotection step of a dioxolane and this is also discussed. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4280 / 4282

页数：3

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