Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells

被引：22

作者：

Lee, Mi Kyeong

Yang, Hyekyung

Yoon, Jeong Seon

Jeong, Eun Ju

Kim, Do Yoon

Ha, Na Ry

Sung, Sang Hyun

Kim, Young Choong ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 07期

关键词：

diterpene; Biota orientalis; HSC-T6; hepatic stellate cells; hepatic fibrosis;

D O I：

10.1007/s12272-001-1239-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antifibrotic effect of twelve diterpenes (1-12) from the 90% methanolic fraction of Biota orientalis leaves was evaluated employing HSC-T6 cells by assessing cell proliferation and morphological change. Among these diterpenes, totarol (8) and isopimara-8(14),15-dien-19-oic acid (9) dramatically reduced cell proliferation in dose- and time-dependent manner. Furthermore, treatment with these compounds resulted in the different pattern of morphological changes of HSC-T6 cells. Taken together, antiproliferative activity of diterpenes from B. orientalis might suggest therapeutic potentials against liver fibrosis.

引用

页码：866 / 871

页数：6

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