Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells

被引：22
|
作者：
Lee, Mi Kyeong
Yang, Hyekyung
Yoon, Jeong Seon
Jeong, Eun Ju
Kim, Do Yoon
Ha, Na Ry
Sung, Sang Hyun
Kim, Young Choong [1 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 07期
关键词：
diterpene; Biota orientalis; HSC-T6; hepatic stellate cells; hepatic fibrosis;
D O I：
10.1007/s12272-001-1239-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antifibrotic effect of twelve diterpenes (1-12) from the 90% methanolic fraction of Biota orientalis leaves was evaluated employing HSC-T6 cells by assessing cell proliferation and morphological change. Among these diterpenes, totarol (8) and isopimara-8(14),15-dien-19-oic acid (9) dramatically reduced cell proliferation in dose- and time-dependent manner. Furthermore, treatment with these compounds resulted in the different pattern of morphological changes of HSC-T6 cells. Taken together, antiproliferative activity of diterpenes from B. orientalis might suggest therapeutic potentials against liver fibrosis.
引用
收藏
页码：866 / 871
页数：6
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