The influence of pellet shape, size and distribution on capsule filling - A preliminary evaluation of three-dimensional computer simulation using a Monte-Carlo technique

被引：24

作者：

Rowe, RC ^{[1
]}

York, P

Colbourn, EA

Roskilly, SJ

机构：

[1] Univ Bradford, Inst Pharmaceut Innovat, PROFITS Grp, Bradford BD7 1DP, W Yorkshire, England

[2] Intelligensys Ltd, Belasis Business Ctr, Billingham TS23 4EA, Cleveland, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 300卷 / 1-2期

关键词：

pellets; capsule filling; computer simulation; Monte-Carlo;

D O I：

10.1016/j.ijpharm.2005.05.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A computer simulation based on a Monte-Carlo technique has been developed and used to investigate the influence of pellet size, dispersity, shape and aggregation on the filling of hard shell capsules. The simulations are in general agreement with experimental observations previously reported. The results also confirm recent findings that filling is a function of pellet shape and that above an aspect ratio value of 1.2 filling reproducibility is reduced. The methodology is simple and rapid in execution allowing many computer-based experiments to be performed with minimum effort. (c) 2005 Published by Elsevier B.V.

引用

页码：32 / 37

页数：6

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