N-Acylsuccinimides: Efficient acylative coupling reagents in palladium-catalyzed Suzuki coupling via C-N cleavage

被引：40
|
作者：
Cui, Ming [1 ]
Chen, Zeyu [2 ]
Liu, Tingting [1 ]
Wang, Hui [1 ]
Zeng, Zhuo [1 ,3 ]
机构：
[1] South China Normal Univ, Coll Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China
[2] Xishuangbanna Entry Exit Inspect & Quarantine Bur, Jinghong 666100, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 LingLing Rd, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 40期
基金：
中国国家自然科学基金;
关键词：
Amide C-N bond cleavage; N-Acylsuccinimides; Diaryl ketones; Acylative Suzuki coupling; High atom utilization; CARBOXYLIC ANHYDRIDES; ARYLBORONIC ACIDS; TWISTED AMIDES; ORGANOBORON COMPOUNDS; ROTATIONAL PATHWAY; KETONE SYNTHESIS; ACYL CHLORIDES; ESTERS; ACYLSACCHARINS; ACTIVATION;
D O I：
10.1016/j.tetlet.2017.08.044
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An acylative Suzuki coupling of activated amides with aryl boronic acids has been reported via palladium-catalyzed C-N bond cleavage. This protocol demonstrate amides can be activated by an atom-economic and cheap succinimide, which can be efficiently utilized to synthesize broad array of diaryl ketones in moderate to good yields. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3819 / 3822
页数：4
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