The Protective Effect of Stichopus Japonicus Fucoidan on PC12 Cells With Hypoxia/Reoxygenation Injury

被引：0
|
作者：
Song, Shuliang [1 ]
Wang, Wei [1 ]
Wang, Xiaochen [1 ]
Liang, Hao [1 ]
Wang, Yunshan [1 ]
Ji, Aiguo [1 ]
机构：
[1] Shandong Univ, Weihai Int Biotechnol R&D Ctr, Weihai 262409, Peoples R China
来源：
MECHATRONICS ENGINEERING, COMPUTING AND INFORMATION TECHNOLOGY | 2014年 / 556-562卷
关键词：
Stichopus Japonicus; Fucoidan; Hypoxia/Reoxygenation Injury; APOPTOSIS; BRAIN; MODEL;
D O I：
10.4028/www.scientific.net/AMM.556-562.610
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
In this study the effect of fucoidan SJP-3 extracted from Stichopus Japonicus was used to evaluate the protective effect on PC12 cells with hypoxia/reoxygenation injury. SJP-3 can stabilize the mitochondrial membrane potential and resistant Cyt-C/mitochondrial apoptotic pathway via increasing the Bcl-2 expression and decreasing expression of the Bax, caspase-3, caspase-9 suggesting that SJP-3 may exert a protective effects on neural cells with hypoxia/reoxygenation injury through the protection of mitochondria, the stability of mitochondrial membrane potential and inhibition of mitochondrial apoptosis pathway.
引用
收藏
页码：610 / 614
页数：5
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