Serum anti-GM2 and anti-GalNAc-GD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis

被引：4

作者：

Halstead, S. K. ^{[1
]}

Gourlay, D. S. ^{[1
]}

Penderis, J. ^{[2
]}

Bianchi, E. ^{[3
]}

Dondi, M. ^{[3
]}

Wessmann, A. ^{[4
]}

Musteata, M. ^{[5
]}

Le Chevoir, M. ^{[6
]}

Martinez-Anton, L. ^{[7
]}

Bhatti, S. F. M. ^{[8
]}

Volk, H. ^{[9
]}

Mateo, I ^{[10
]}

Tipold, A. ^{[9
]}

Ives, E. ^{[11
]}

Pakozdy, A. ^{[12
]}

Gutierrez-Quintana, R. ^{[13
]}

Brocal, J. ^{[14
]}

Whitehead, Z. ^{[15
]}

Granger, N. ^{[16
,17
]}

Pazzi, P. ^{[15
]}

Harcourt-Brown, T. ^{[18
]}

Jose-Lopez, R. ^{[13
]}

Rupp, S. ^{[19
]}

Schenk, H. C. ^{[20
]}

Smith, P. ^{[21
]}

Gandini, C. ^{[22
]}

Menchetti, M. ^{[23
]}

Mortera-Balsa, V ^{[24
]}

Rusbridge, C. ^{[25
,26
]}

Tauro, A. ^{[7
]}

Cozzi, F. ^{[27
]}

Deutschland, M. ^{[28
]}

Tirrito, F. ^{[27
]}

Freeman, P. ^{[29
]}

Lowrie, M. ^{[30
]}

Jackson, M. R. ^{[31
]}

Willison, H. J. ^{[1
]}

Rupp, A. ^{[13
]}

机构：

[1] Univ Glasgow, Inst Infect Immun & Inflammat, Neuroimmunol Lab, Glasgow G12 8TA, Lanark, Scotland

[2] Broadleys Vet Hosp, Vet Extra Neurol, Stirling FK7 7LE, Scotland

[3] Univ Parma, Dept Vet Sci, I-43126 Parma, Italy

[4] Pride Vet Ctr, Neurol & Neurosurg Serv, Pride Pk, Derby DE24 8HX, England

[5] Univ Agr Sci & Vet Med, Fac Vet Med, Neurol Serv, Iasi 700489, Romania

[6] Univ Melbourne, Dept Neurol & Neurosurg, Werribee, Vic 3030, Australia

[7] Telford Court, Chestergates CH1 6LT, England

[8] Univ Ghent, Small Anim Teaching Hosp, Fac Vet Med, Small Anim Dept, B-9820 Merelbeke, Belgium

[9] Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany

[10] Univ Alfonso X Sabio, Serv Neurol, Hosp Clin Vet, Madrid, Spain

[11] Anderson Moores Vet Specialists, Hursley SO21 2LL, Winchester, England

[12] Univ Vet Med, Univ Hosp Small Anim, Vienna, Austria

[13] Univ Glasgow, Sch Vet Med, Glasgow G61 1QH, Lanark, Scotland

[14] Wear Referrals Vet Hosp, Bradbury TS21 2ES, Stockton On Tee, England

[15] Univ Pretoria, Fac Vet Sci, Dept Compan Anim Clin Studies, ZA-0110 Onderstepoort, South Africa

[16] Univ London, Royal Vet Coll, Hatfield, Herts, England

[17] Bristol Vet Specialists Highcroft, CVS Referrals, Bristol, Avon, England

[18] Univ Bristol, Sch Vet Sci, Langford Vet Serv, Lower Langford BS40 5DU, England

[19] Tierklin Hofheim, D-65719 Hofheim, Germany

[20] Tierklin Luneburg, D-21337 Luneburg, Germany

[21] Hamilton Specialist Referrals, Cressex Business Pk, High Wycombe HP12 3SD, Bucks, England

[22] Univ Bologna, Dept Vet Med Sci, I-40064 Ozzano Dellemilia, Italy

[23] San Marco Vet Clin, Neurol & Neurosurg Div, Veggiano, Italy

[24] North Downs Specialist Referrals, 3 & 4 Brewerst Dairy Business Pk, Bletchingley RH1 4QP, Surrey, England

[25] Fitzpatrick Referrals, Neurol Sect, Godalming GU2 7AL, Surrey, England

[26] Univ Surrey, Fac Hlth & Med Sci, Sch Vet Med, Guildford GU2 7AL, Surrey, England

[27] Clin Neurol Vet, I-20148 Milan, Italy

[28] Neurol Referral Serv, Berlin, Germany

[29] Queens Vet Sch Hosp, Cambridge CB3 0ES, England

[30] Dovecote Vet Hosp, Derby DE74 2LJ, England

[31] Univ Glasgow, Inst Canc Sci, Bearsden G61 1QH, Scotland

来源：

JOURNAL OF SMALL ANIMAL PRACTICE | 2022年 / 63卷 / 02期

基金：

英国惠康基金; 芬兰科学院;

关键词：

GUILLAIN-BARRE-SYNDROME; ANTIGANGLIOSIDE ANTIBODY; GANGLIOSIDE ANTIBODIES; DEMYELINATING POLYNEUROPATHY; IDIOPATHIC POLYNEUROPATHY; COMPLEMENT; NEUROPATHY; DOGS; DESTRUCTION; GALNAC-GD1A;

D O I：

10.1111/jsap.13439

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Objectives A previous single-country pilot study indicated serum anti-GM2 and anti-GA1 anti-glycolipid antibodies as potential biomarkers for acute canine polyradiculoneuritis. This study aims to validate these findings in a large geographically heterogenous cohort. Materials and Methods Sera from 175 dogs clinically diagnosed with acute canine polyradiculoneuritis, 112 dogs with other peripheral nerve, cranial nerve or neuromuscular disorders and 226 neurologically normal dogs were screened for anti-glycolipid antibodies against 11 common glycolipid targets to determine the immunoglobulin G anti-glycolipid antibodies with the highest combined sensitivity and specificity for acute canine polyradiculoneuritis. Results Anti-GM2 anti-glycolipid antibodies reached the highest combined sensitivity and specificity (sensitivity: 65.1%, 95% confidence interval 57.6 to 72.2%; specificity: 90.2%, 95% confidence interval 83.1 to 95.0%), followed by anti-GalNAc-GD1a anti-glycolipid antibodies (sensitivity: 61.7%, 95% confidence interval 54.1 to 68.9%; specificity: 89.3%, 95% confidence interval 82.0 to 94.3%) and these anti-glycolipid antibodies were frequently present concomitantly. Anti-GA1 anti-glycolipid antibodies were detected in both acute canine polyradiculoneuritis and control animals. Both for anti-GM2 and anti-GalNAc-GD1a anti-glycolipid antibodies, sex was found a significantly associated factor with a female to male odds ratio of 2.55 (P=0.0096) and 3.00 (P=0.0198), respectively. Anti-GalNAc-GD1a anti-glycolipid antibodies were more commonly observed in dogs unable to walk (odds ratio 4.56; P=0.0076). Clinical Significance Anti-GM2 and anti-GalNAc-GD1a immunoglobulin G anti-glycolipid antibodies represent serum biomarkers for acute canine polyradiculoneuritis.

引用

页码：104 / 112

页数：9

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