SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF CONFORMATIONALLY CONSTRAINED CYANOGUANIDINES: POTENT AND SELECTIVE HISTAMINE H4 RECEPTOR AGONISTS

被引:0
|
作者
Geyer, R. [1 ]
Igel, P. [1 ]
Bernhardt, G. [1 ]
Buschauer, A. [1 ]
机构
[1] Univ Regensburg, Inst Pharm, Dept Med Chem 2, D-93040 Regensburg, Germany
关键词
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:S353 / S354
页数:2
相关论文
共 50 条
  • [21] Screening of histaminergic ligands for histamine H4 receptor activity:: discovery of a potent and selective H4R agonist
    Lim, HD
    Bakker, RA
    Thurmond, RL
    Leurs, R
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2006, 373 (01) : 94 - 94
  • [22] Synthesis and Evaluation of Structurally Constrained Quinazolinone Derivatives as Potent and Selective Histamine H3 Receptor Inverse Agonists
    Nagase, Tsuyoshi
    Mizutani, Takashi
    Sekino, Etsuko
    Ishikawa, Shiho
    Ito, Sayaka
    Mitobe, Yuko
    Miyamoto, Yasuhisa
    Yoshimoto, Ryo
    Tanaka, Takeshi
    Ishihara, Akane
    Takenaga, Norihiro
    Tokita, Shigeru
    Sato, Nagaaki
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (21) : 6889 - 6901
  • [23] A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties
    Thurmond, RL
    Desai, PJ
    Dunford, PJ
    Fung-Leung, WP
    Hofstra, CL
    Jiang, W
    Nguyen, S
    Riley, JP
    Sun, SQ
    Williams, KN
    Edwards, JP
    Karlsson, L
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 309 (01): : 404 - 413
  • [24] Structure-activity relationships of histamine H2 receptor ligands
    Dove, S
    Elz, S
    Seifert, R
    Buschauer, A
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2004, 4 (09) : 941 - 954
  • [25] Structure-Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4 Receptor Ligands
    Altenbach, Robert J.
    Adair, Ronald M.
    Bettencourt, Brian M.
    Black, Lawrence A.
    Fix-Stenzel, Shannon R.
    Gopalakrishnan, Suiatha M.
    Hsieh, Gin C.
    Liu, Huaqing
    Marsh, Kennan C.
    McPherson, Michael J.
    Milicic, Ivan
    Miller, Thomas R.
    Vortherms, Timothy A.
    Warrior, Usha
    Wetter, Jill M.
    Wishart, Neil
    Witte, David G.
    Honore, Prisca
    Esbenshade, Timothy A.
    Hancock, Arthur A.
    Brioni, Jorge D.
    Cowart, Marlon D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (20) : 6571 - 6580
  • [26] PHARMACOLOGICAL CHARACTERIZATION OF OXIME AGONISTS OF THE HISTAMINE H4 RECEPTOR
    Yu, F.
    Wolin, R. L.
    Wei, J.
    Desai, P. J.
    McGovern, P. M.
    Dunford, P. J.
    Karlsson, L.
    Thurmond, R. L.
    INFLAMMATION RESEARCH, 2010, 59 : S327 - S327
  • [27] Functional characterization of inverse agonists at the histamine H4 receptor
    Schneider, E. H.
    Thurmond, R.
    Seifert, R.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2009, 379 : 14 - 14
  • [28] Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists
    Tarzia, G
    Duranti, A
    Tontini, A
    Spadoni, G
    Mor, M
    Rivara, S
    Plazzi, PV
    Kathuria, S
    Piomelli, D
    BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (18) : 3965 - 3973
  • [29] Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists
    Fonquerna, S
    Miralpeix, M
    Pagès, L
    Puig, C
    Cardús, A
    Antón, F
    Vilella, D
    Aparici, N
    Prieto, J
    Warrellow, G
    Beleta, J
    Ryder, H
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (04) : 1165 - 1167
  • [30] Synthesis and structure-activity relationships of potent retinoid X receptor ligands
    Farmer, LJ
    Jeong, S
    Kallel, EA
    Koch, SSC
    Croston, GE
    Flatten, KS
    Heyman, RA
    Nadzan, AM
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (18) : 2393 - 2398