Silver-Promoted Regioselective Oxidative Decarboxylative C-H Alkylation of Phenanthridines with Carboxylic Acids

被引：5

作者：

Huang, Tianyin ^{[1
]}

Yu, Yang ^{[1
]}

Wang, Hui ^{[1
]}

Lin, Yifan ^{[1
]}

Ma, Yurui ^{[1
]}

Wang, Haoyu ^{[1
]}

Ding, Chang-Hua ^{[1
]}

Xiao, Junjie ^{[1
]}

Xu, Bin ^{[1
,2
]}

机构：

[1] Shanghai Univ, Sch Life Sci, Qianweichang Coll, Dept Chem,Innovat Drug Res Ctr, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 02期

基金：

中国国家自然科学基金;

关键词：

phenanthridine; decarboxylation; silver acetate; C-H alkylation; potassium persulfate; late-stage modification; ISOCYANIDE INSERTION; 6-SUBSTITUTED PHENANTHRIDINES; RADICAL REACTIONS; CYCLIZATION; ACCESS; DERIVATIVES; ISONITRILES; ACTIVATION; ANNULATION; CYANATION;

D O I：

10.1055/s-0039-1690220

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel oxidative decarboxylative C-H alkylation of phenanthridines with carboxylic acids was developed for the efficient synthesis of multi-substituted phenanthridine derivatives. The given method features easy availability of starting materials, high regioselectivity, and mild conditions. Furthermore, a one-pot synthesis of multi-substituted phenanthridine derivatives was realized by the reaction of biphenyl isocyanides and carboxylic acid.

引用

页码：239 / 245

页数：7

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