In Vivo Wound-Healing Effects of Novel Benzalkonium Chloride-Loaded Hydrocolloid Wound Dressing

被引：26

作者：

Jin, Sung Giu ^{[1
,2
]}

Yousaf, Abid Mehmood ^{[1
,2
]}

Jang, Sun Woo ^{[3
]}

Son, Mi-Won ^{[3
]}

Kim, Kyung Soo ^{[1
,2
]}

Kim, Dong-Wuk ^{[1
,2
]}

Li, Dong Xun ^{[4
]}

Kim, Jong Oh ^{[5
]}

Yong, Chul Soon ^{[5
]}

Choi, Han-Gon ^{[1
,2
]}

机构：

[1] Hanyang Univ, Coll Pharm, Ansan 426791, South Korea

[2] Hanyang Univ, Inst Pharmaceut Sci & Technol, Ansan 426791, South Korea

[3] Dong A Pharm Co Ltd, Pharmaceut Prod Res Labs, Yongin 449905, Kyunggi Do, South Korea

[4] Jiangxi Univ Tradit Chinese Med, Natl Pharmaceut Engn Ctr Solid Preparat Chinese H, Nanchang 330006, Jiangxi, Peoples R China

[5] Yeungnam Univ, Coll Pharm, Gyongsan 712749, South Korea

来源：

DRUG DEVELOPMENT RESEARCH | 2015年 / 76卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

benzalkonium chloride; wound dressing; wound healing; abrasion wound; excision wound; infection wound; SODIUM ALGINATE; POLYVINYL-ALCOHOL; CHITOSAN; DELIVERY; SKIN; COMPOSITE; HYDROGELS; RELEASE; SYSTEM; MATRIX;

D O I：

10.1002/ddr.21253

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The purpose of this study was to evaluate the wound-healing effects of a novel benzalkonium chloride (BC)-loaded hydrocolloid wound dressing (HCD). A BC-loaded HCD was prepared with various constituents using a hot melting method, and its mechanical properties and antimicrobial activities were assessed. The in vivo wound healings of the BC-loaded HCD in various would models were evaluated in rats compared with a commercial wound dressing, Duoderm. This BC-loaded HCD gave better skin adhesion, swelling, mechanical strength, and flexibility compared with the commercial wound dressing. It showed excellent antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. In addition, as compared with the commercial wound dressing, it showed more improved wound healings and tissue restoration effect on the excision, infection, and abrasion wounds in rats. Thus, this novel BC-loaded HCD would be an excellent alternative to the commercial wound dressing for treatment of various wounds. Drug Dev Res 73 : 157-165, 2015. (c) 2015 Wiley Periodicals, Inc.

引用

页码：157 / 165

页数：9

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