CETUXIMAB AS PRIMARY TREATMENT FOR CUTANEOUS SQUAMOUS CELL CARCINOMA TO THE NECK

被引：21
|
作者：
Kim, Sung [1 ]
Eleff, Michael [2 ]
Nicolaou, Nicos [3 ]
机构：
[1] Canc Inst New Jersey, New Brunswick, NJ USA
[2] Canc Inst New Jersey, Hamilton, NJ USA
[3] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 02期
关键词：
cutaneous; squamous cell carcinoma; SCC; metastatic; cetuximab; PLUS CETUXIMAB; HEAD; SKIN;
D O I：
10.1002/hed.21299
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. Head and neck cutaneous squamous cell carcinoma (SCC) metastatic to lymph nodes is commonly treated with surgery plus radiotherapy. Methods. We present the case of a 92-year-old man with cutaneous SCC metastatic to the neck (7 cm) who was treated with primary cetuximab and has had a durable complete response for 7 months. Because of his age, comorbidities, and unresectable neck lymphadenopathy, he received primary cetuximab. He received a 400 mg/m(2) loading dose and a 250 mg/m2 weekly dose for 3 months and then had to discontinue as a result of other unrelated medical issues. Results. The patient had a complete response by 6 weeks. Seven months after discontinuing cetuximab, he continues to have a complete response. Conclusions. Primary cetuximab for cutaneous SCC metastatic to lymph nodes is an area that bears further investigation because of its apparent efficacy and excellent toxicity profile. (C) 2009 Wiley Periodicals, Inc. Head Neck 33: 286 288, 2011
引用
收藏
页码：286 / 288
页数：3
相关论文
共 50 条
  • [41] Cutaneous Squamous Cell Carcinoma of the Head and Neck Management of the Parotid and Neck
    Yilmaz, Metin
    Eskiizmir, Gorkem
    Friedman, Oren
    FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA, 2012, 20 (04) : 473 - +
  • [42] Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck
    D'Souza, Jacob
    Clark, Jonathan
    CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY, 2011, 19 (02): : 99 - 105
  • [43] Cetuximab A Review of its Use in Squamous Cell Carcinoma of the Head and Neck
    Frampton, James E.
    DRUGS, 2010, 70 (15) : 1987 - 2010
  • [44] Circulating tumor cell abundance in head and neck squamous cell carcinoma decreases with successful chemoradiation and cetuximab treatment
    Poellmann, Michael J.
    Bu, Jiyoon
    Kim, DaWon
    Iida, Mari
    Hong, Heejoo
    Wheeler, Deric L.
    Kimple, Randall J.
    Wang, Andrew Z.
    Hong, Seungpyo
    CANCER LETTERS, 2023, 562
  • [45] Matrisomal genes in squamous cell carcinoma of head and neck influence tumor cell motility and response to cetuximab treatment
    Goh, Kah Yee
    Lau, Kah Weng
    De Cheng, Terence You
    Tham, Su Chin
    Lim, Chwee Teck
    Iyer, Narayanan Gopalakrishna
    Lim, Su Bin
    Lim, Darren Wan-Teck
    CANCER COMMUNICATIONS, 2022, 42 (04) : 355 - 359
  • [46] Circulating tumor cell abundance in head and neck squamous cell carcinoma decreases with successful chemoradiation and cetuximab treatment
    Kenmogne, Claudie F.
    Eckhardt, Paul
    Tchuenguem, Roland T.
    Gross, Jonathan
    Ngouafong, Francis T.
    Ponou, Beaudelaire K.
    Dzoyem, Jean P.
    Teponno, Remy B.
    Opatz, Till
    Tapondjou, Leon A.
    TETRAHEDRON LETTERS, 2023, 120
  • [47] Evaluation of the treatment of head and neck cutaneous squamous cell carcinoma in the elderly: a survival analysis
    Bernal Martinez, Alvaro Jesus
    Fernandez Letamendi, Nieves
    Delgado Martinez, Julio
    Gomez-Escolar Larranaga, Lucia
    Reola Ramirez, Enara
    Puertas Pena, Javier
    CIRUGIA ESPANOLA, 2018, 96 (09): : 577 - 582
  • [48] Metastatic patterns and treatment options for head and neck cutaneous squamous cell carcinoma (Review)
    Iancu, Doriana
    Fulga, Ana
    Vesa, Doina
    Zenovia, Andrei
    Fulga, Iuliu
    Sarbu, Mihaela Ionela
    Tatu, Alin Laurentiu
    MOLECULAR AND CLINICAL ONCOLOGY, 2024, 20 (06)
  • [49] A Phase II Trial of Adjuvant Cetuximab and Radiation Therapy in Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
    Kreinbrink, P. J.
    Mierzwa, M. L.
    Redmond, K. P.
    Wise-Draper, T.
    Casper, K.
    Takiar, V.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2020, 108 (03): : E800 - E800
  • [50] Treatment results of regional metastasis from cutaneous head and neck squamous cell carcinoma
    Jol, JAD
    van Velthuysen, MLF
    Hilgers, FJM
    Keus, RB
    Neering, H
    Balm, AJM
    EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 2003, 29 (01): : 81 - 86
12345