Low-dose neuroleptic therapy and relapse in schizophrenia: Meta-analysis of randomized controlled trials

被引：9
|
作者：
Barbui, C
Saraceno, B
Liberati, A
Garattini, S
机构：
[1] Mario Negri Inst. for Pharmacol. R., 20157 Milan
来源：
EUROPEAN PSYCHIATRY | 1996年 / 11卷 / 06期
关键词：
schizophrenia; neuroleptics; low-dose; meta-analysis;
D O I：
10.1016/S0924-9338(96)89899-3
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
We assessed the relative efficacy and effectiveness of low-versus standard-dose neuroleptic therapy in reducing relapse rate in schizophrenic patients. Six long-term randomized controlled trials were retrieved through a MEDLINE search. A dose regimen between 50 and 100 mg equivalent of chlorpromazine, compared to a conventional one between 200 and 500 mg, was found to increase the Likelihood of relapse in chronic schizophrenic patients. Differences, however, were statistically significant at 12 but not at 24 months of treatment.
引用
收藏
页码：306 / 313
页数：8
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