Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of doxorubicin for breast cancer therapy

被引：16
|
作者：
Cao, Shunxiu [1 ]
Guo, Jiamin [1 ]
He, Yujing [2 ]
Alahdal, Murad [1 ]
Tang, Shanshan [1 ]
Zhao, Yuekui [1 ]
Yang, Zhaocong [1 ]
Gao, Huashan [1 ]
Hu, Wenjun [1 ]
Jiang, Hulin [2 ]
Qin, Lianju [3 ]
Jin, Liang [1 ]
机构：
[1] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Dept Pharmaceut, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2018年 / 46卷
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
Mesenchymal stem cells; nanoparticles; artificial cells; targeted delivery; doxorubicin; breast cancer; ANTICANCER DRUG-DELIVERY; STROMAL CELLS; NANOPARTICLES; SYSTEMS; NANOCARRIERS; METASTASES; MUTATION;
D O I：
10.1080/21691401.2018.1434185
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The main challenge of anticancer drugs is poor tumor targeting. Now cellular carriers are widely investigated to deliver anticancer agents. As an ideal cellular candidate, human umbilical cord derived mesenchymal stem cells (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed hUC-MSCs carrying transferrin-inspired-nanoparticles that contain doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and made an evaluation. Results represented that hUC-MSCs-Tf-inspired-NPs not only exhibit the controlled-release property of Tf-inspired-NPs, but also integrate tumor tropism and penetrative abilities of MSCs. The tumor volume of nude mice bearing breast cancer MCF-7 treated with hUC-MSCs-Tf-inspired-NPs, was remarkably reduced compared to those treated with free drug or Tf-inspired-NPs. Thus, Tf-inspired-NPs loaded hUC-MSCs have a potential to deliver anticancer drugs.
引用
收藏
页码：S642 / S652
页数：11
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