Induction of haptoglobin by all-trans retinoic acid in THP-1 human monocytic cell line

被引：18
|
作者：
Kim, IS
Lee, IH
Lee, JH
Lee, SY
机构：
[1] Catholic Univ Korea, Coll Med, Dept Nat Sci, Chem Sect, Seoul 137701, South Korea
[2] Catholic Univ Korea, Coll Med, Dept Biochem, Seoul 137701, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 284卷 / 03期
关键词：
acute-phase protein; haptoglobin; all-trans retinoic acid; differentiation; THP-1 cell line;
D O I：
10.1006/bbrc.2001.5041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Haptoglobin (Hp) is one of the acute-phase proteins and is mainly synthesized in the liver. During our study on the differentiation of leukemia cells, we have found that Hp is synthesized in human monocytic cells by all-trans retinoic acid (ATRA). The synthesis of Hp by ATRA is induced in a dose- and time-dependent manner, Hp cDNA cloned from ATRA-treated THP-1 cells corresponds to the Hp alpha2(FS)-beta form. Whereas ATRA acted as a strong inducer in THP-1 cells, IL-1 beta, TNF-alpha, IL-6, and LPS had little effect on Hp gene expression in these cells, These findings suggest that THP-1 cells express the Hp gene through a signal pathway different from hepatocytes, and that ATRA is a potent Hp-inducer in these cells. (C) zool Academic Press.
引用
收藏
页码：738 / 742
页数：5
相关论文
共 50 条
  • [21] Synergistic effect of the association of all-trans retinoic acid and melphalan on the induction of apoptosis in human myeloma cell lines
    Maschke, S
    Thomas, AM
    Dhuiege, E
    Lefebvre, O
    Zandecki, M
    Bauters, F
    Formstecher, P
    Facon, T
    BLOOD, 1996, 88 (10) : 415 - 415
  • [22] Evidence for nicotinic cholinergic receptors on a monocytic cell line (THP-1)
    Morgan, D
    Parsons, ME
    Whelan, CJ
    BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131
  • [23] Differential expression of dendritic cell markers by all-trans retinoic acid on human acute promyelocytic leukemic cell line
    Park, HY
    Park, JY
    Kim, JW
    Lee, MJ
    Jang, MJ
    Lee, SY
    Baek, DW
    Park, YM
    Lee, SW
    Yoon, S
    Bae, YS
    Kwak, JY
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2004, 4 (13) : 1587 - 1601
  • [24] Differentiation induction of all-trans retinoic acid (ATRA) resistant myeloid cell line and its redox regulation.
    Sumimoto, Y
    Maeda, Y
    Nawata, H
    Miyatake, J
    Sono, H
    Sakaguchi, M
    Matsuda, M
    Tatsumi, Y
    Urase, F
    Horiuchi, F
    Kanamaru, A
    BLOOD, 1998, 92 (10) : 197B - 197B
  • [25] Bradycardia during induction therapy with all-trans retinoic acid (ATRA)
    Karakatsanis, S.
    Vardaka, M.
    Giannoulia, P.
    Apostolidis, J.
    Delimpasi, S.
    JOURNAL OF BUON, 2014, 19 (01): : 315 - 315
  • [26] Effects of all-trans retinoic acid and 9-cis retinoic acid in human retinoblastoma cell lines
    Gupta, A
    Van Quill, KR
    Sharara, NA
    O'Brien, JM
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U370 - U370
  • [27] Binding characteristics of human lactoferrin to the human monocytic leukemia cell line THP-1 differentiated into macrophages
    Eda, S
    Kikugawa, K
    Beppu, M
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1996, 19 (02) : 167 - 175
  • [28] The Monocytic Cell Line THP-1 as a Validated and Robust Surrogate Model for Human Dendritic Cells
    Hoelken, Johanna Maria
    Teusch, Nicole
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (02)
  • [29] Internalization of different Mycobacterium avium subsp paratuberculosisstrains in the human monocytic cell line THP-1
    Borrmann, E.
    Moebius, P.
    Hinsching, A.
    Muselmann, C.
    Koehler, H.
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2012, 302 : 63 - 63
  • [30] CD4 is active as a signaling molecule on the human monocytic cell line Thp-1
    Graziani-Bowering, GM
    Filion, LG
    Thibault, P
    Kozlowski, M
    EXPERIMENTAL CELL RESEARCH, 2002, 279 (01) : 141 - 152
12345