Could SARS-CoV-2 Infection Be a Novel Risk Factor for Multiple Sclerosis?

被引:2
|
作者
Magdy, Rehab [1 ]
Hussein, Mona [2 ]
机构
[1] Cairo Univ, Kasr Al Ainy Fac Med, Dept Neurol, Cairo, Egypt
[2] Beni Suef Univ, Dept Neurol, Bani Suwayf, Egypt
关键词
Severe acute respiratory syndrome coronavirus-2; Multiple sclerosis; Molecular mimicry; Blood-brain barrier; Cytokine storm; PATHOGENESIS; CELLS; OC43; RNA;
D O I
10.1159/000521891
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The outbreak of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has challenged the healthcare community worldwide. The SARS-CoV-2 primarily affects the respiratory system; however, strong evidence suggests that SARS-CoV-2 can be neuroinvasive, resulting in several neurological complications. It was previously assumed that some coronaviruses are involved in multiple sclerosis (MS) pathology via various mechanisms. The mechanisms involved in coronavirus-induced central demyelination are complex and largely redundant. Molecular mimicry was proposed to be one of the possible mechanisms. Disruption of the blood-brain barrier, dysregulation in several inflammatory cytokines, and upregulation of matrix metalloproteinases were also thought to induce central demyelinating pathology. This raises a question about the possible role of SARS-CoV-2 as a novel risk factor for MS.
引用
收藏
页码:251 / 254
页数:4
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