SARS-CoV-2 Seropositivity and Seroconversion in Patients Undergoing Active Cancer-Directed Therapy

被引：2

作者：

Sun, Lova ^{[1
]}

Surya, Sanjna ^{[1
]}

Goodman, Noah G. ^{[1
]}

Le, Anh N. ^{[1
]}

Kelly, Gregory ^{[1
]}

Owoyemi, Olutosin ^{[1
]}

Desai, Heena ^{[1
]}

Zheng, Cathy ^{[1
]}

DeLuca, Shannon ^{[1
]}

Good, Madeline L. ^{[1
]}

Hussain, Jasmin ^{[2
]}

Jeffries, Seth D. ^{[1
]}

Kry, Yolanda R. ^{[2
]}

Kugler, Emily M. ^{[1
]}

Mansour, Maikel ^{[2
]}

Ndicu, John ^{[1
]}

Osei-Akoto, Annaclaire ^{[3
]}

Prior, Timothy ^{[2
]}

Pundock, Stacy L. ^{[1
]}

Varughese, Lisa A. ^{[3
]}

Weaver, JoEllen ^{[3
]}

Doucette, Abigail ^{[4
]}

Dudek, Scott ^{[3
]}

Verma, Shefali Setia ^{[3
]}

Gouma, Sigrid ^{[5
]}

Weirick, Madison E. ^{[5
]}

McAllister, Christopher M. ^{[5
]}

Bange, Erin ^{[1
]}

Gabriel, Peter ^{[4
,6
]}

Ritchie, Marylyn ^{[3
]}

Rader, Daniel J. ^{[3
]}

Vonderheide, Robert H. ^{[1
,6
]}

Schuchter, Lynn M. ^{[1
,6
]}

Verma, Anurag ^{[3
]}

Maillard, Ivan ^{[1
,6
]}

Mamtani, Ronac ^{[1
,6
]}

Hensley, Scott E. ^{[5
]}

Gross, Robert ^{[7
]}

Wileyto, E. Paul ^{[8
]}

Huang, Alexander C. ^{[1
,6
]}

Maxwell, Kara N. ^{[1
,3
,6
]}

DeMichele, Angela ^{[1
,6
]}

机构：

[1] Univ Penn, Dept Med, Div Hematol Oncol, Perelman Sch Med, Philadelphia, PA USA

[2] Univ Penn, Dept Neurosurg, Perelman Sch Med, Philadelphia, PA USA

[3] Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA USA

[4] Univ Penn, Dept Radiat Oncol, Perelman Sch Med, Philadelphia, PA USA

[5] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA

[6] Univ Penn, Abramson Canc Ctr, Philadelphia, PA USA

[7] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA USA

[8] Univ Penn, Dept Biostat Epidemiol & Informat, Perelman Sch Med, Philadelphia, PA USA

来源：

JCO ONCOLOGY PRACTICE | 2021年 / 17卷 / 12期

基金：

美国国家卫生研究院;

关键词：

COVID-19; IMPACT;

D O I：

10.1200/OP.21.00113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSE Multiple studies have demonstrated the negative impact of cancer care delays during the COVID-19 pandemic, and transmission mitigation techniques are imperative for continued cancer care delivery. We aimed to gauge the effectiveness of these measures at the University of Pennsylvania. METHODS We conducted a longitudinal study of SARS-CoV-2 antibody seropositivity and seroconversion in patients presenting to infusion centers for cancer-directed therapy between May 21, 2020, and October 8, 2020. Participants completed questionnaires and had up to five serial blood collections. RESULTS Of 124 enrolled patients, only two (1.6%) had detectable SARS-CoV-2 antibodies on initial blood draw, and no initially seronegative patients developed newly detectable antibodies on subsequent blood draw(s), corresponding to a seroconversion rate of 0% (95% CI, 0.0 TO 4.1%) over 14.8 person-years of follow up, with a median of 13 health care visits per patient. CONCLUSION These results suggest that patients with cancer receiving in-person care at a facility with aggressive mitigation efforts have an extremely low likelihood of COVID-19 infection. (C) 2021 by American Society of Clinical Oncology

引用

页码：748 / +

页数：9

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