Age-Related Macular Degeneration (AMD): Alzheimer's Disease in the Eye?

被引：201

作者：

Kaarniranta, Kai ^{[1
,2
]}

Salminen, Antero ^{[3
,4
]}

Haapasalo, Annakaisa ^{[3
,4
]}

Soininen, Hilkka ^{[3
,4
]}

Hiltunen, Mikko ^{[3
,4
]}

机构：

[1] Univ Eastern Finland, Dept Ophthalmol, Inst Clin Med, FIN-70211 Kuopio, Finland

[2] Kuopio Univ Hosp, Dept Ophthalmol, SF-70210 Kuopio, Finland

[3] Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland

[4] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2011年 / 24卷 / 04期

基金：

芬兰科学院;

关键词：

Age-related macular degeneration (AMD); aggregation; aging; Alzheimer's disease; autophagy; lysosome; oxidative stress; proteasome; COMPLEMENT FACTOR-H; MITOCHONDRIAL-DNA DAMAGE; RETINAL-PIGMENT EPITHELIUM; MILD COGNITIVE IMPAIRMENT; HTRA1 PROMOTER POLYMORPHISM; UBIQUITIN-PROTEASOME SYSTEM; AMYLOID PRECURSOR PROTEIN; GLYCATION END-PRODUCTS; VASCULAR RISK-FACTORS; E EPSILON-4 ALLELE;

D O I：

10.3233/JAD-2011-101908

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease that shares several clinical and pathological features with Alzheimer's disease (AD), including stress stimuli such as oxidative stress and inflammation. In both diseases, the detrimental intra- and extracellular deposits have many similarities. Aging, hypercholesterolaemia, hypertension, obesity, arteriosclerosis, and smoking are risk factors to develop AMD and AD. Cellular aging processes have similar organelle and signaling association in the retina and brain tissues. However, it seems that these diseases have a different genetic background. In this review, differences and similarities of AMD and AD are thoroughly discussed.

引用

页码：615 / 631

页数：17

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