Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury

被引：77

作者：

Chen, Yunqing ^{[1
]}

Fan, Hongyan ^{[2
]}

Wang, Shijun ^{[2
]}

Tang, Guanmin ^{[2
]}

Zhai, Changlin ^{[2
]}

Shen, Liang ^{[2
]}

机构：

[1] Jiaxing Univ, Dept Infect Dis, Affiliated Hosp, Jiaxing, Peoples R China

[2] Jiaxing Univ, Dept Cardiol, Affiliated Hosp, Jiaxing, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

关键词：

ferroptosis; Ischemia; reperfusion injury; iron; lipid peroxidation; therapeutic target; CELL-DEATH PATHWAYS; ISCHEMIA/REPERFUSION INJURY; DEGRADATION; METABOLISM; REGULATOR; MECHANISM; APOPTOSIS; AUTOPHAGY; STRESS; FAILS;

D O I：

10.3389/fcell.2021.688605

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ischemia-reperfusion (I/R) injury is a major cause of cell death and organ damage in numerous pathologies, including myocardial infarction, stroke, and acute kidney injury. Current treatment methods for I/R injury are limited. Ferroptosis, which is a newly uncovered type of regulated cell death characterized by iron overload and lipid peroxidation accumulation, has been investigated in various diseases. There is increasing evidence of a close association between ferroptosis and I/R injury, with ferroptosis frequently identified as a new therapeutic target for the management of I/R injury. This review summarizes the current status of ferroptosis and discusses its relationship with I/R injury, as well as potential treatment strategies targeting it.

引用

页数：9

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