Imino glycals in synthesis:: Preparation of novel deoxymannojirimycin analogues

被引：0

作者：

Désiré, J ^{[1
]}

Shipman, M ^{[1
]}

机构：

[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

来源：

SYNLETT | 2001年 / 08期

关键词：

carbohydrates; piperidines; stereoselective synthesis; imino glycals; glycosidases;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of imino glucal 2 from tetra-O-benzyl-D-glucopyranose in 7 steps is described. This imino sugar building block is converted into conformationally constrained deoxymannojirimycin analogue (+)-9 by means of a stereocontrolled cyclopropanation followed by a two step deprotection sequence. Regioselective fission of the cyclopropane ring prior to deprotection provides access to related analogue (+)-11.

引用

页码：1332 / 1334

页数：3

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