MicroRNA Profiling in Asthma: Potential Biomarkers and Therapeutic Targets

被引：52

作者：

Heffler, Enrico ^{[1
,2
]}

Allegra, Alessandro ^{[3
]}

Pioggia, Giovanni ^{[4
]}

Picardi, Giuseppe ^{[6
]}

Musolino, Caterina ^{[3
]}

Gangemi, Sebastiano ^{[4
,5
]}

机构：

[1] Humanitas Univ, Humanitas Res Hosp, Personalized Med Asthma & Allergy Clin, Milan, Italy

[2] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[3] Univ Messina, Dept Gen Surg & Oncol, Div Hematol, Messina, Italy

[4] Univ Hosp G Martino, Messina Unit, Inst Appl Sci & Intelligent Syst, Messina, Italy

[5] Univ Hosp G Martino, Dept Clin & Expt Med, Sch & Div Allergy & Clin Immunol, Messina, Italy

[6] Univ Catania, Dept Clin & Expt Med, Resp Dis & Allergy, Catania, Italy

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2017年 / 57卷 / 06期

关键词：

asthma; biomarkers; cytokine; exosome; miRNA; AIRWAY SMOOTH-MUSCLE; BRONCHIAL EPITHELIAL-CELLS; MESENCHYMAL TRANSITION; CIRCULATING MICRORNAS; ALLERGIC RHINITIS; GABA(A) RECEPTORS; T-CELLS; EXPRESSION; DIFFERENTIATION; ACTIVATION;

D O I：

10.1165/rcmb.2016-0231TR

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Asthma is a heterogeneous chronic inflammatory disorder in which different endotypes contribute to define clinical inflammatory phenotypes. MicroRNAs (miRNAs) are a group of minute, endogenous 22-25 nt RNA elements that join to particular mRNAs to reduce translation and increase messenger RNA degradation. miRNAs operate in post-transcriptional control and regulate physiological and pathological processes in several illnesses. The purpose of this work is to review and discuss the current knowledge about the function of miRNAs in asthma, focusing particularly on their biological properties, pathophysiologic actions, and possible use as markers and treatments for asthma.

引用

页码：642 / 650

页数：9

共 50 条

[21] Plasma Microrna Profiling Reveals Potential Biomarkers of Thiazide Response
Chekka, Lakshmi Manasa S.
Langaee, Taimour Y.
Wang, Danxin
Rolf, Renne
Chapman, Arlene B.
Gums, John
Turner, Stephen T.
Cooper-Dehoff, Rhonda M.
Johnson, Julie A.
CIRCULATION, 2020, 142
[22] WHOLE BLOOD MICRORNA PROFILING REVEALS POTENTIAL BIOMARKERS OF SEPSIS
van der Sluijs, K. F.
Tuip-de Boer, A. M.
de Beer, F. M.
Bos, L. D.
Straat, M.
Wieske, L.
van Vught, L. A.
Huson, M. A.
Horn, J.
Schultz, M. J.
Wieland, C. W.
INTENSIVE CARE MEDICINE, 2013, 39 : S337 - S337
[23] MicroRNA Expression Profiling Identifies Potential Prognostic Biomarkers in Osteosarcoma
Liang, Y.
Wani, K.
Long, L.
Deavers, M. T.
Lazar, A. J.
Aldape, K. D.
Wang, W-L
LABORATORY INVESTIGATION, 2014, 94 : 22A - 22A
[24] MicroRNA Expression Profiling Identifies Potential Prognostic Biomarkers in Osteosarcoma
Liang, Y.
Wani, K.
Long, L.
Deavers, M. T.
Lazar, A. J.
Aldape, K. D.
Wang, W-L
MODERN PATHOLOGY, 2014, 27 : 22A - 22A
[25] MicroRNA-181 in cardiovascular disease: Emerging biomarkers and therapeutic targets
Lv, Bingjie
He, Shaolin
Li, Peixin
Jiang, Shijiu
Li, Dazhu
Lin, Jibin
Feinberg, Mark W.
FASEB JOURNAL, 2024, 38 (09):
[26] Transcriptome profiling of lentigos identifies potential therapeutic targets
Maeno, H.
Hayashi, Y.
Prouty, S.
O'Day, C.
Honma, Y.
Seykora, J.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (05) : S214 - S214
[27] MicroRNA as novel biomarkers and therapeutic targets in diabetic kidney disease: An update
Cao, Qinghua
Chen, Xin-Ming
Huang, Chunling
Pollock, Carol A.
FASEB BIOADVANCES, 2019, 1 (06) : 375 - 388
[28] MicroRNA epigenetic alterations: predicting biomarkers and therapeutic targets in human diseases
Wang, Y.
Liang, Y.
Lu, Q.
CLINICAL GENETICS, 2008, 74 (04) : 307 - 315
[29] lncRNAs: potential therapeutic targets and biomarkers for pancreatic cancer?
Montes, Marta
Arnes, Luis
EXPERT OPINION ON THERAPEUTIC TARGETS, 2021, 25 (07) : 521 - 528
[30] MiRNA as potential biomarkers and therapeutic targets for gastric cancer
Vivian Yvonne Shin
Kent-Man Chu
World Journal of Gastroenterology, 2014, (30) : 10432 - 10439

← 1 2 3 4 5 →