-Perfluoroalkyl Peroxides as Fluorinated C3-Building Blocks for the Construction of Benzo[4,5]imidazo[1,2-a]pyridines

被引：6

作者：

Ma, Yangyang ^{[1
]}

Lv, Leiyang ^{[1
]}

Li, Zhiping ^{[1
]}

机构：

[1] Renmin Univ China, Dept Chem, Key Lab Adv Light Convers Mat & Biophoton, Beijing 100872, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 02期

基金：

中国国家自然科学基金;

关键词：

CATALYZED CARBONYLATION-PEROXIDATION; TRIFLUOROMETHYLATION; ANNULATION; DERIVATIVES; STYRENES; INDOLES; ARENES; BENZO;

D O I：

10.1021/acs.joc.1c02589

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and selective protocol for the synthesis of perfluoroalkyl-group-substituted benzo[4,5]imidazo[1,2-a]-pyridines has been developed in which beta-perfluoroalkyl peroxides act as novel fluorinated C3-building blocks to implement regioselective [3 + 3] annulation with 2-cyanomethyl benzimidazole under metal-free conditions. The application of the synthesized perfluoroalkylated BIPs as potent anticancer reagents versus the nonfluorinated ones demonstrated the biological utility of this method.

引用

页码：1564 / 1573

页数：10

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