-Perfluoroalkyl Peroxides as Fluorinated C3-Building Blocks for the Construction of Benzo[4,5]imidazo[1,2-a]pyridines

被引：6
|
作者：
Ma, Yangyang [1 ]
Lv, Leiyang [1 ]
Li, Zhiping [1 ]
机构：
[1] Renmin Univ China, Dept Chem, Key Lab Adv Light Convers Mat & Biophoton, Beijing 100872, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 02期
基金：
中国国家自然科学基金;
关键词：
CATALYZED CARBONYLATION-PEROXIDATION; TRIFLUOROMETHYLATION; ANNULATION; DERIVATIVES; STYRENES; INDOLES; ARENES; BENZO;
D O I：
10.1021/acs.joc.1c02589
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and selective protocol for the synthesis of perfluoroalkyl-group-substituted benzo[4,5]imidazo[1,2-a]-pyridines has been developed in which beta-perfluoroalkyl peroxides act as novel fluorinated C3-building blocks to implement regioselective [3 + 3] annulation with 2-cyanomethyl benzimidazole under metal-free conditions. The application of the synthesized perfluoroalkylated BIPs as potent anticancer reagents versus the nonfluorinated ones demonstrated the biological utility of this method.
引用
收藏
页码：1564 / 1573
页数：10
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